Evidence map›Paper›PMID 40139692›Full record

ArticleInterdisciplinary cardiovascular and thoracic surgery2025

Long-term mortality after coronary surgery in women patients depend on diabetes and age.

Victor Dayan, Juan Andres Montero, Maximiliano Hernandez, Carolina Sosa, Santiago Cubas, Stefano Urso, Rafael Sadaba, Nick Freemantle

Abstract read
In one paragraph

Article in Interdisciplinary cardiovascular and thoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Victor DayanHospital de Clinicas, Universidad de la Republica, Montevideo, Uruguay.ORCID 0000-0002-5470-0585
Juan Andres MonteroHospital de Clinicas, Universidad de la Republica, Montevideo, Uruguay.
Maximiliano HernandezInstituto Nacional de Cirugia Cardiaca, Montevideo, Uruguay.
Carolina SosaHospital de Clinicas, Universidad de la Republica, Montevideo, Uruguay.
Santiago CubasHospital de Clinicas, Universidad de la Republica, Montevideo, Uruguay.
Stefano UrsoCardiac Surgery Department, Hospital Universitario Dr Negrín, Las Palmas de Gran Canaria, Spain.ORCID 0000-0002-7239-3195
Rafael SadabaCardiac Surgery Department, Hospital Universitario de Navarra, Pamplona, Spain.
Nick FreemantleComprehensive Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK.ORCID 0000-0001-5807-5740

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThere is general consensus of the higher short-term risk in women after coronary artery bypass grafts (CABG), nonetheless, long-term survival is a matter of debate. We aimed to compare in a national database with over 10 years of follow-up long-term survival in women versus men and its interaction with diabetes and age.

methodsThis is a national retrospective cohort study from Uruguay. Patients were included if they underwent isolated CABG between 1 January 2002 and 31 December 2022. The primary outcome was survival. The secondary outcome was a composite of operative mortality, postoperative stroke, deep sternal wound infection and kidney failure requiring dialysis. Interaction of age and diabetes was explored in the survival analysis after adjusting for baseline characteristics.

resultsDuring the included study period, 21 959 patients (5778 were women) underwent isolated CABG in Uruguay. Among people with diabetes, women had worse survival, while no differences between gender were found in the non-diabetic population. Survival at 1 year after CABG was significantly lower in women (hazard ratio (HR) = 1.20; 95% confidence interval (CI): 1.07, 1.35; P = 0.002). Survival after 1-year was higher in women (P < 0.001). Absence of diabetes improved survival (HR = 0.83; 95% CI: 0.77, 0.89; P < 0.001), while presence of diabetes made survival between men and women similar (HR = 1.00; 95% CI: 0.92, 1.09; P = 0.946). Interaction between age and gender showed that women older than 60 years old had better survival than men. Composite outcome was worse in women (OR = 1.47; 95% CI: 1.24, 1.75).

conclusionsWomen patients have worse overall mortality but better long-term survival than men. Diabetes and age have significant interaction with the long-term outcomes. Better survival is seen in women older than 60 years old.

Indexed as

Coronary Artery BypassCoronary Artery DiseaseDiabetes MellitusPostoperative ComplicationsAgedAge FactorsDatabases, FactualFemaleHumansMaleMiddle AgedRetrospective StudiesRisk AssessmentRisk FactorsSex FactorsTime FactorsCABGgendersurvival

Identifiers

PMID40139692
PMCPMC11954628

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.