Evidence map›Paper›PMID 40140071›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2025

Hepatic microtubule destabilization facilitates liver fibrosis in the mouse model of Wilson disease.

Som Dev, Yixuan Dong, James P Hamilton

Abstract read
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Som DevDepartment of Biochemistry, All India Institute of Medical Sciences, Kalyani, West Bengal, 741245, India. som.biochem@aiimskalyani.edu.in.ORCID http://orcid.org/0000-0003-1934-1019
Yixuan DongDepartment of Physiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
James P HamiltonDepartment of Physiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.

Funding

Copper Homeostasis and Liver FunctionR01DK117396 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JAMES P HAMILTON, SVETLANA LUTSENKO · 2018 to 2026
$3.9M
NIDDK NIH HHS R01 DK117396NIDDK NIH HHS RO1- DK117396
6 · The paper itself

Abstract

Wilson disease (WD) is a potentially fatal metabolic disorder caused by the inactivation of the copper (Cu) transporter ATP7B, resulting in systemic Cu overload and fibroinflammatory liver disease. The molecular mechanism and effects of elevated Cu on cytoskeletal dynamics in liver fibrogenesis are not clear. Here, we tested the regulation of hepatic cytoskeleton and fibrogenesis with respect to Cu overload in WD. Atp7b

Indexed as

Hepatolenticular DegenerationLiverLiver CirrhosisMicrotubulesAcetylationAnimalsCopperCopper-Transporting ATPasesDisease Models, AnimalHepatocytesMaleMiceMice, KnockoutTubulinAtp7b protein, mouseCopperCopper-Transporting ATPasesTubulinAtp7bCopperFibrosisMicrotubulesTubulin stabilityWilson disease

Identifiers

PMID40140071
PMCPMC12078373

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.