Evidence map›Paper›PMID 40140147›Full record

SynthesisJournal of neurovirology2025

Bidirectional relationship between human herpes virus reactivation and depression: a systematic review and meta-analysis.

Arman Shafiee, Zahra Nakhaee, Mohammad Javad Amini, Fatemeh Esmailpur Abianeh, Mana Goodarzi, Samira Parvizi Omran, Hamed Hajishah, Dina Sadeghi, Aida Rezaei Nejad, Mahmood Bakhtiyari

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of neurovirology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arman ShafieeStudent Research Committee, Alborz University of Medical Sciences, Karaj, Iran. armanshafieemd@gmail.com.
Zahra NakhaeeStudent Research Committee, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
Mohammad Javad AminiStudent Research Committee, Alborz University of Medical Sciences, Karaj, Iran.
Fatemeh Esmailpur AbianehSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mana GoodarziSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Samira Parvizi OmranSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Hamed HajishahSchool of Medicine, Islamic Azad University of Medical Sciences, Tehran, Iran.
Dina SadeghiSchool of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Aida Rezaei NejadSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mahmood BakhtiyariNon-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. mahmood.bakhtiyari@ymail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman herpesviruses (HHVs) are lifelong pathogens that can reactivate under stress or immunological changes. Depression has been implicated as both a potential trigger for and a consequence of HHV reactivation. This study investigates the bidirectional relationship between HHV reactivation and depression through a systematic review and meta-analysis.

methodsThis systematic review and meta-analysis followed PRISMA guidelines and was registered in PROSPERO (CRD42024565616). A search of PubMed, Web of Science, Embase, and Scopus identified studies published through March 5, 2024.

resultsNineteen studies, representing a total sample size of 94,194 participants, were included in the meta-analysis. The pooled odds ratio (OR) demonstrated a significant association between HHV reactivation and depression (OR = 1.33; 95% CI: 1.07-1.64; p < 0.001; I

conclusionThis study provides evidence of a bidirectional relationship between HHV reactivation and depression, highlighting depression as both a risk factor for and a potential consequence of HHV reactivation.

Indexed as

DepressionHerpesviridae InfectionsVirus ActivationCytomegalovirusEpstein-Barr Virus InfectionsHerpesviridaeHerpesvirus 2, HumanHerpesvirus 4, HumanHumansDepressionEBVHerpes virusHSVReactivationVZV

Identifiers

PMID40140147

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.