Articlenpj aging2025
Butylphthalide identified via Samul-tang-induced transcriptomic signatures improves oocyte quality in aged mice.
Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
Abstract
Samul-tang (SM) is a traditional prescription widely used in clinical practice for the management of gynecological diseases, especially for menstrual regulation and infertility treatment. We previously reported its efficacy in increasing mature oocyte production and improving ovarian reserves, potentially regulated by rat sarcoma virus (Ras) signaling in the ovaries of aged mice. Although the main ingredients of SM are known, the bioactive compounds responsible for protecting ovarian function during aging remain unidentified. This study aimed to identify the active compounds that significantly contribute to the therapeutic potential of SM against age-related decline in ovarian function. The combination of butylphthalide and oleanolic acid improved mature oocyte production similar to that in SM-administered aged mice. Subsequently, we identified butylphthalide as an active compound that mimicked SM's effect on enhancing ovarian reserve. This study introduces a novel strategy for identifying active compounds in multi-component herbal medicines by evaluating compound combinations in an in vivo model, offering promising therapeutic avenues for age-related female infertility through targeted gene expression modulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.