ArticleScientific reports2025
The association between periodontitis and arterial stiffening among the hypertensive middle-aged and elderly U.S. Population.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Arterial stiffening is an independent predictor of cardiovascular diseases, closely associated with hypertension and aging. Periodontitis, a chronic inflammatory disease caused by microbial imbalances, has been linked to systemic inflammation and endothelial dysfunction. This study aims to investigate the association between periodontitis and arterial stiffening in hypertensive individuals. Data utilized in this study were sourced from the 2009-2014 National Health and Nutrition Examination Survey (NHANES). A total of 3165 hypertensive patients aged ≥ 50 years were enrolled. The relationship between the severity of periodontitis and arterial stiffening (PP ≥ 60) was analyzed using multivariate logistic regression model. Moreover, the associations between pocket depth (PD) and clinical attachment loss (CAL) with arterial stiffening were investigated using multivariate logistic regression model and restricted cubic splines. Among the patients, 1223 (39%) exhibited no or mild periodontal disease, while 1447 (46%) and 495 (15%) were diagnosed with moderate and severe periodontal disease, respectively. Moderate and severe periodontitis were associated with higher odds of arterial stiffening compared to no/mild periodontitis in the fully adjusted model (moderate: OR 1.30 [95% CI 1.09-1.55], P = 0.004; severe: OR 1.35 [95% CI 1.05-1.73], P = 0.019; P for trend < 0.001). Higher quartiles of PD and CAL scores were significantly associated with greater odds of arterial stiffening (PD Q4 vs. Q1: OR 1.41 [95% CI 1.12-1.79], P = 0.004; CAL Q4 vs. Q1: 1.31 [95% CI 1.03-1.67], P = 0.030), with evidence of linear dose-response relationships (P
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