Evidence map›Paper›PMID 40140558›Full record

ArticleNature biotechnology2026

Specific and efficient RNA A-to-I editing through cleavage of an ADAR inhibitor.

Guangye Li, Guo Chen, Guo-Hua Yuan, Jia Wei, Qingyang Ni, Jing Wu, Bei Yang, Li Yang, Jia Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Emerging clinical applications of ADAR based RNA editing.Stem cells translational medicine · 2025
    Review
  8. Spotlight on cancer immunotherapies.Nature biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guangye Li *Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Guo Chen *Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Guo-Hua Yuan *Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-8459-3784
Jia Wei *Center for Molecular Medicine, Children's Hospital of Fudan University and Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Qingyang NiGene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0009-0001-7727-4080
Jing WuGene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Bei YangGene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0001-5389-3859
Li YangCenter for Molecular Medicine, Children's Hospital of Fudan University and Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China. liyang_fudan@fudan.edu.cn.ORCID http://orcid.org/0000-0001-8833-7473
Jia ChenGene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, China. chenjia@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0002-4242-2899

Funding

Ministry of Agriculture and Rural Affairs of the People's Republic of China (MOA) NK2022010207Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2023YFC3403402Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2023ZD0500501Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2024YFA1803301Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2024YFC3405902National Natural Science Foundation of China (National Science Foundation of China) 32070170National Natural Science Foundation of China (National Science Foundation of China) 32371514National Natural Science Foundation of China (National Science Foundation of China) 32430018Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 23DX1900102Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 23JS1400300Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 23XD1422500Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 23ZR1442500
6 · The paper itself

Abstract

RNA editing can be a promising therapeutic approach. However, ectopic expression of RNA editing enzymes has been shown to trigger off-target editing. Here we identified adenosine deaminase acting on RNA (ADAR) inhibitors (ADIs) that suppress the activity of the fused ADAR2 deamination domain (ADAR2

Indexed as

AdenosineAdenosine DeaminaseAdenosine Deaminase InhibitorsRNA-Binding ProteinsRNA EditingAnimalsHEK293 CellsHumansMiceADAR protein, humanAdenosineAdenosine DeaminaseAdenosine Deaminase InhibitorsRNA-Binding Proteins

Identifiers

PMID40140558

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.