ArticleNature2025
Oxidation of retromer complex controls mitochondrial translation.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Retromer-targeted therapy for neurodegenerative diseases.Molecular neurodegeneration · 2026Review
- A lysis-derived PMSF and orthovanadate oxidant defines a distinct cysteine-engagement profile.Cell chemical biology · 2026Article
- Multidrug resistance in cancer: current understandings and future perspective.Molecular biomedicine · 2026Review
- Redox-triggered USP18 confers cisplatin resistance in ovarian cancer by selectively activating a non-canonical FSP1-dependent ferroptosis escape pathway.Redox biology · 2026Article
- Arvanil reverses cisplatin resistance in ovarian cancer by activating HMOX1-driven ferroptosis.Scientific reports · 2026Article
- Mitochondrial translational control in cardiovascular diseases: from mechanisms to therapies.Redox biology · 2026Review
- Epicatechin Gallate Ameliorates UVB-Induced Photoaging by Inhibiting p38α-Mediated Autophagy and Oxidative Stress.Antioxidants (Basel, Switzerland) · 2026Article
- Targeting mitochondrial homeostasis as a cancer treatment strategy: current status and future prospects.Molecular cancer · 2026Review
- Extracellular Vesicles, Nutrient Balance, and Redox Metabolism During Epididymal Sperm Maturation: A Perspective on the Complexity of Intercellular Interplay.Advances in anatomy, embryology, and cell biology · 2026Review
- Serum Metabolomic Profiles Predict Sensitivity and Toxicity to Platinum- Fluorouracil Chemotherapy in a Gastric Cancer Xenograft Model.Combinatorial chemistry & high throughput screening · 2026Article
- LEAP2 triggers retromer-mediated membrane trafficking of MOSPD2 to promote chemotaxis in teleost monocytes/macrophages.Zoological research · 2025Article
- Review
- Oxidative Stress and Inflammation: Drivers of Tumorigenesis and Therapeutic Opportunities.Antioxidants (Basel, Switzerland) · 2025Review
- miR-512-3p/RPS6KA2 Axis Regulates Cisplatin Resistance in Ovarian Cancer via Autophagy and Ferroptosis.Oncology research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors.
Junbing Zhang *Krantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA. junbingzhang@sinh.ac.cn.ORCID 0000-0001-7746-1145
Md Yousuf Ali *Krantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
Harrison Byron Chong *Krantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
Pei-Chieh TienKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.ORCID 0000-0002-0012-0155
James WoodsDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Carolina NobleKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.ORCID 0000-0002-9527-536X
Tristan VornbäumenKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
Zehra OrduluBrigham and Women's Hospital, Department of Pathology, Harvard Medical School, MA, USA.ORCID 0000-0002-3218-1075
Anthony P PossematoCell Signaling Technology, Danvers, MA, USA.
Stefan HarryKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
Jay Miguel FonticellaKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
Lina FellahKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
Drew HarrisonKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.ORCID 0009-0009-5232-0640
Maolin GeKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.ORCID 0000-0002-8803-1463
Neha KhandelwalKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.ORCID 0000-0001-7831-6820
Yingfei HuangKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
Maëva ChauvinPediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-0129-5480
Anica Tamara BischofKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
Grace Marie HambeltonDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-0893-6773
Magdy Farag GoharKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
Siwen ZhangKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
MinGyu ChoiDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sara BouberhanDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Esther OlivaDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Mari Mino-KenudsonDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Natalya N PavlovaDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Michael LawrenceKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.
Justin F GainorDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-8697-4081
Sean A BeausoleilCell Signaling Technology, Danvers, MA, USA.ORCID 0000-0002-3356-4641
Nabeel BardeesyKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.ORCID 0000-0003-3867-0416
Raul MostoslavskyDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-7740-5212
David PépinPediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-2046-6708
Christopher J OttKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA.ORCID 0000-0001-6142-7241
Brian LiauDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-2985-462X
Liron Bar-PeledKrantz Family Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, MA, USA. lbar-peled@mgh.harvard.edu.ORCID 0000-0003-2687-9546
Funding
Mapping Structure-Activity Relationships of Chemical Inhibitors via Genome-EditingDP2GM137494 · NIGMS · HARVARD UNIVERSITY · PI LIAU, BRIAN · 2019 to 2019
$2.5MA novel, glutathione-dependent metabolic pathway drives metastatic outgrowth in pancreatic cancerR01CA279173 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Raul Mostoslavsky · 2024 to 2026
$2.4MIdentification of Covalent Transcriptional Dependencies in MelanomaR01CA285415 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Liron Bar-Peled, Brian Liau · 2024 to 2026
$2.0MDeciphering the Role of Reductive Stress in Non Small Cell Lung CancerR37CA260062 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Liron Bar-Peled · 2022 to 2026
$1.9MIntegrating Chemical Genetic Approaches with Precision Genome EditingR35GM153476 · NIGMS · HARVARD UNIVERSITY · PI Brian Liau · 2024 to 2026
$1.2MMapping druggable co-dependency pathways in NRF2-driven lung cancersR00CA215249 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BAR-PELED, LIRON · 2019 to 2021
$727kDefining Nuclear H2O2 Regulation by Covalent RegulatorsR21AG083413 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI BAR-PELED, LIRON · 2023 to 2023
$459kNCI NIH HHS R00 CA215249NCI NIH HHS R01 CA279173NCI NIH HHS R01 CA285415NCI NIH HHS R37 CA260062NIA NIH HHS R21 AG083413NIGMS NIH HHS DP2 GM137494NIGMS NIH HHS R35 GM153476
Abstract
Reactive oxygen species (ROS) underlie human pathologies including cancer and neurodegeneration
Indexed as
MitochondriaProtein BiosynthesisVesicular Transport ProteinsAnimalsCell MembraneCysteineCytosolEndosomesFemaleHumansHydrogen PeroxideMiceOvarian NeoplasmsOxidation-ReductionReactive Oxygen SpeciesCysteineHydrogen PeroxideReactive Oxygen SpeciesVesicular Transport ProteinsVPS35 protein, human
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What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.