Evidence map›Paper›PMID 40140755›Full record

ArticleMolecular medicine (Cambridge, Mass.)2025

Identifying nexilin as a central gene in neutrophil-driven abdominal aortic aneurysm pathogenesis.

Bohan Yang, Yiyan Xu, Fengfei Yan, Cheng Peng, Ye Song, Song Han, Haiyang Wang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bohan YangDepartment of Vascular Surgery, The First Affiliated Hospital of Guangzhou Medical University, No. 151, Yanjiang West Road, Yuexiu District, Guangzhou, China.
Yiyan XuDepartment of Vascular Surgery, The First Affiliated Hospital of Guangzhou Medical University, No. 151, Yanjiang West Road, Yuexiu District, Guangzhou, China.
Fengfei YanDepartment of Vascular Surgery, The First Affiliated Hospital of Guangzhou Medical University, No. 151, Yanjiang West Road, Yuexiu District, Guangzhou, China.
Cheng PengDepartment of Vascular Surgery, The First Affiliated Hospital of Guangzhou Medical University, No. 151, Yanjiang West Road, Yuexiu District, Guangzhou, China.
Ye SongDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Song HanDepartment of Vascular Surgery, The First Affiliated Hospital of Guangzhou Medical University, No. 151, Yanjiang West Road, Yuexiu District, Guangzhou, China.
Haiyang WangDepartment of Vascular Surgery, The First Affiliated Hospital of Guangzhou Medical University, No. 151, Yanjiang West Road, Yuexiu District, Guangzhou, China. haiyanghmu@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAbdominal aortic aneurysm (AAA) is an inflammation-driven disease in which neutrophil infiltration is critical to its progression. This study aims to explore the molecular mechanisms behind neutrophil infiltration in AAA and identify key regulatory genes.

methodsWe utilized weighted gene co-expression network analysis (WGCNA) and differential gene expression analysis to compare AAA and healthy abdominal aortic tissues. Functional enrichment analysis and a protein-protein interaction (PPI) network were constructed to understand gene functions. Machine learning algorithms were applied to identify key hub genes, followed by in vivo validation using an ApoE-/- mouse model.

resultsNeutrophils, NK cells, and pDCs were significantly increased in AAA tissues. WGCNA identified 234 genes associated with neutrophil infiltration, of which 39 were significantly differentially expressed. Functional enrichment analysis highlighted roles in actin-related processes and pathways. Nexilin (NEXN) was consistently identified as a key hub gene negatively correlated with immune cell infiltration. In vivo validation confirmed that NEXN inhibits AAA progression in ApoE-/- mice by regulating immune cell infiltration.

conclusionNEXN plays a crucial role in modulating neutrophil infiltration in AAA. These findings provide new molecular insights into AAA pathogenesis and suggest NEXN as a potential target for AAA therapy.

Indexed as

Aortic Aneurysm, AbdominalNeutrophil InfiltrationNeutrophilsAnimalsApolipoproteins EDisease Models, AnimalGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansMaleMiceMice, KnockoutProtein Interaction MapsApolipoproteins EAbdominal aortic aneurysmImmune cell infiltrationMachine learningNeutrophilsNexilinWeighted gene co-expression network analysis

Identifiers

PMID40140755
PMCPMC11948811

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.