Evidence map›Paper›PMID 40141244›Full record

ArticleInternational journal of molecular sciences2025

Implementation and One-Year Evaluation of Proenkephalin A in Critical Care.

Lukas Martin, Caren Martin, Arne Peine, Matthias Imöhl, Alexander Kersten, Rafael Kramann, Turgay Saritas, Nikolaus Marx, Michael Dreher, Gernot Marx and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lukas MartinDepartment of Intensive Care Medicine, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Caren MartinDepartment of Intensive Care Medicine, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0009-0004-5899-6370
Arne PeineDepartment of Intensive Care Medicine, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Matthias ImöhlLaboratory Diagnostic Center, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0002-8372-0251
Alexander KerstenDepartment of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0002-4919-7866
Rafael KramannDepartment of Nephrology, Rheumatology, Clinical Immunology and Hypertension, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Turgay SaritasDepartment of Nephrology, Rheumatology, Clinical Immunology and Hypertension, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0002-6691-9218
Nikolaus MarxDepartment of Cardiology, Angiology and Internal Intensive Care Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Michael DreherDepartment of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0002-3452-5329
Gernot MarxDepartment of Intensive Care Medicine, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Tim-Philipp SimonDepartment of Intensive Care Medicine, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proenkephalin A 119-159 (PENK) is a promising functional kidney biomarker, evaluated in various clinical settings. In critical care medicine, early diagnosis of acute kidney injury (AKI) is crucial; however, to date, the diagnosis and the assessment of kidney function is still based on serum creatinine (sCr) and urine output, both associated with several limitations. Between November 2020 and March 2022, we implemented PENK in our daily practice on our intensive care units (ICU). PENK, sCr, AKI stage, and the start and duration of renal replacement therapy (RRT) were documented. Almost 18,000 PENK measurements from 4169 patients were analyzed, and the glomerular filtration rate (GFR) was estimated with the new PENK-GFR formula. PENK outperformed sCR in the kidney function assessment and sCR trajectory over time. Moreover, PENK predicted the use of RRT and thus showed its usefulness in critical care daily practice.

Indexed as

Acute Kidney InjuryCritical CareEnkephalinsProtein PrecursorsAgedBiomarkersCreatinineFemaleGlomerular Filtration RateHumansIntensive Care UnitsMaleMiddle AgedRenal Replacement TherapyBiomarkersCreatinineEnkephalinsproenkephalinProtein PrecursorsAKIcritical carekidney function biomarkerPENKproenkephalin Aproenkephalin A 119–159

Identifiers

PMID40141244
PMCPMC11942029

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.