Evidence map›Paper›PMID 40141250›Full record

ArticleInternational journal of molecular sciences2025

Low Plasma Carnosinase-1 Activity in Patients with Left Ventricular Systolic Dysfunction: Implications for Carnosine Therapy in Heart Failure.

I-Chau Liang, Ettore Gilardoni, Islam A Berdaweel, Knute D Carter, Ethan J Anderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

I-Chau LiangDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-4849-333X
Ettore GilardoniDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA.
Islam A BerdaweelDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA.ORCID 0009-0006-2987-458X
Knute D CarterDepartment of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.
Ethan J AndersonDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-0113-8875

Funding

Determinants of cardioprotection by circulating prohibitin-1 during sepsisR01HL167087 · NHLBI · UNIVERSITY OF IOWA · PI Ethan John Anderson · 2023 to 2026
$1.8M
American Heart Association 20SFRN35200003NHLBI NIH HHS R01 HL167087NHLBI NIH HHS R01HL167087
6 · The paper itself

Abstract

Therapeutic efficacy of histidyl dipeptides such as carnosine is hampered by circulating carnosinase-1 (CN1), which catalyzes carnosine's hydrolysis and degradation. Prior reports suggest that oral carnosine may improve cardiometabolic parameters in patients with heart failure (HF), but whether CN1 activity is affected by HF is unknown. Here, we measured CN1 content and carnosine degradation rate (CDR) in preoperative plasma samples from a cohort of patients (

Indexed as

CarnosineDipeptidasesHeart FailureVentricular Dysfunction, LeftAgedFemaleHumansMaleMiddle Agedaminoacyl-histidine dipeptidaseCarnosineDipeptidasescarnosinasecarnosineCN1 proteinCNDP1heart failure

Identifiers

PMID40141250
PMCPMC11942450

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.