Evidence map›Paper›PMID 40141315›Full record

ArticleInternational journal of molecular sciences2025

Developmental Endothelial Locus-1 Promotes Osteoclast Differentiation and Activation.

Kentaro Imamura, Keita Tachi, Tadahiro Takayama, Hironori Kasai, Ryutaro Shohara, Kenji Inoue, Yoichiro Taguchi, Saki Nakane-Koyachi, Atsushi Saito, Seiichi Yamano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kentaro ImamuraDepartment of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 101-0061, Japan.ORCID 0000-0001-6428-3677
Keita TachiKomazawa Parkside Dental Clinic, Setagaya-ku, Tokyo 154-0021, Japan.
Tadahiro TakayamaDepartment of Periodontology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo 101-0062, Japan.
Hironori KasaiKasai Dental Clinic, Kitakyushu-shi 800-0226, Fukuoka, Japan.ORCID 0000-0002-8288-6460
Ryutaro ShoharaShohara Dental Clinic, Osaka-shi 543-0013, Osaka, Japan.
Kenji InoueDepartment of Prosthodontics, New York University College of Dentistry, New York, NY 10010, USA.ORCID 0000-0003-3946-9538
Yoichiro TaguchiDepartment of Operative Dentistry, Endodontology and Periodontology, Matsumoto Dental University, Shiojiri-shi 399-0704, Nagano, Japan.
Saki Nakane-KoyachiDepartment of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 101-0061, Japan.
Atsushi SaitoDepartment of Periodontology, Tokyo Dental College, Chiyoda-ku, Tokyo 101-0061, Japan.ORCID 0000-0002-0065-2207
Seiichi YamanoDepartment of Prosthodontics, New York University College of Dentistry, New York, NY 10010, USA.

Funding

Greater New York Academy of Prosthodontics naMultidisciplinary Research Center for Jaw Disease, Tokyo Dental College na
6 · The paper itself

Abstract

Developmental endothelial locus-1 (DEL-1) has traditionally been characterized within the scientific community as having anti-inflammatory properties with potential inhibitory effects on osteoclast formation. Our investigation challenges this paradigm by examining

Indexed as

Calcium-Binding ProteinsCell DifferentiationOsteoclastsOsteogenesisAnimalsCell Adhesion MoleculesFemaleMacrophagesMiceMice, Inbred C57BLRANK LigandRAW 264.7 CellsCalcium-Binding ProteinsCell Adhesion MoleculesEdil3 protein, mouseRANK Ligandbone metabolismDEL-1osteoclastsosteoporosis

Identifiers

PMID40141315
PMCPMC11942430

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.