Evidence map›Paper›PMID 40141345›Full record

ArticleInternational journal of molecular sciences2025

Nephrectomy Induces Severe Bone Loss in Mice Expressing Constitutively Active TGFβ Receptor Type I.

Parichart Toejing, Ohnmar Myint, Asada Leelahavanichkul, Somyoth Sridurongrit, Matthew B Greenblatt, Sutada Lotinun

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Parichart ToejingCenter of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0009-0007-3073-0214
Ohnmar MyintCenter of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0001-9004-4282
Asada LeelahavanichkulDivision of Immunology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-5566-6403
Somyoth SridurongritDepartment of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Matthew B GreenblattDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Sutada LotinunCenter of Excellence in Skeletal Disorders and Enzyme Reaction Mechanism, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-5127-3039

Funding

A skeletal stem cell orchestrating limb regenerationR01HD115274 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI Matthew Blake Greenblatt, Xu Yang · 2024 to 2026
$1.8M
Discovery of a stem cell governing vertebral physiologyR01AR083462 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Matthew Blake Greenblatt · 2024 to 2026
$1.5M
NIAMS NIH HHS R01 AR083462NICHD NIH HHS R01 HD115274Thailand Science Research and Innovation Fund, Faculty Research Grant, Faculty of Dentistry, and the Second Century Fund (C2F), Chulalongkorn University. DRF 68_024
6 · The paper itself

Abstract

Transforming growth factor beta (TGF-β), a master regulator of renal fibrosis, is the hallmark of chronic kidney disease (CKD) progression, and CKD worsens bone remodeling. However, the effects of the dysregulation of

Indexed as

Bone ResorptionNephrectomyReceptor, Transforming Growth Factor-beta Type IRenal Insufficiency, ChronicAnimalsBone Diseases, MetabolicBone RemodelingDisease Models, AnimalMaleMiceMice, TransgenicOsteoblastsOsteogenesisTransforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type ITransforming Growth Factor betabonechronic kidney diseaseosteoblastosteoclastTGFβ

Identifiers

PMID40141345
PMCPMC11943261

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.