Evidence map›Paper›PMID 40141458›Full record

ArticleInternational journal of molecular sciences2025

Differential Response and Recovery Dynamics of HSPC Populations Following

Federica Bruno, Christiana Georgiou, Deirdre Cunningham, Lucy Bett, Marine A Secchi, Samantha Atkinson, Sara González Antón, Flora Birch, Jean Langhorne, Cristina Lo Celso

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Differential Response and Recovery Dynamics of HSPC Populations FollowingInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Federica BrunoDepartment of Life Sciences, Imperial College London, London SW10 9NH, UK.
Christiana GeorgiouDepartment of Life Sciences, Imperial College London, London SW10 9NH, UK.
Deirdre CunninghamSir Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0003-2201-3745
Lucy BettDepartment of Life Sciences, Imperial College London, London SW10 9NH, UK.
Marine A SecchiDepartment of Life Sciences, Imperial College London, London SW10 9NH, UK.
Samantha AtkinsonDepartment of Life Sciences, Imperial College London, London SW10 9NH, UK.
Sara González AntónDepartment of Life Sciences, Imperial College London, London SW10 9NH, UK.
Flora BirchDepartment of Life Sciences, Imperial College London, London SW10 9NH, UK.
Jean LanghorneSir Francis Crick Institute, London NW1 1AT, UK.
Cristina Lo CelsoDepartment of Life Sciences, Imperial College London, London SW10 9NH, UK.

Funding

CRUK C36195/A26770Wellcome TrustWellcome Trust 212304/Z/18/Z
6 · The paper itself

Abstract

Severe infections such as malaria are on the rise worldwide, driven by both climate change and increasing drug resistance. It is therefore paramount that we better understand how the host responds to severe infection. Hematopoiesis is particularly of interest in this context because hematopoietic stem and progenitor cells (HSPCs) maintain the turnover of all blood cells, including all immune cells. Severe infections have been widely acknowledged to affect HSPCs; however, this disruption has been mainly studied during the acute phase, and the process and level of HSPC recovery remain understudied. Using a self-resolving model of natural rodent malaria, infection by

Indexed as

Hematopoietic Stem CellsMalariaPlasmodium chabaudiAnimalsCell DifferentiationCell ProliferationDisease Models, AnimalHematopoiesisMiceMice, Inbred C57BLhematopoietic stem and progenitor cellsmalariarecovery from infection

Identifiers

PMID40141458
PMCPMC11943058

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.