Evidence map›Paper›PMID 40141790›Full record

ReviewLife (Basel, Switzerland)2025

Procalcitonin: Infection or Maybe Something More? Noninfectious Causes of Increased Serum Procalcitonin Concentration: Updated Knowledge.

Szymon Mućka, Grzegorz K Jakubiak, Natalia Pawlas

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Non-Infectious Causes for Elevated Procalcitonin.Medicina (Kaunas, Lithuania) · 2026
    Pooled it
  2. Urinary bacterial count as a predictor of concomitant bacteremia in adults with community-acquired Enterobacterales urinary tract infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Szymon MućkaDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 38 St., 41-800 Zabrze, Poland.ORCID 0000-0002-2934-5649
Grzegorz K JakubiakDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 38 St., 41-800 Zabrze, Poland.ORCID 0000-0003-0039-8306
Natalia PawlasDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 38 St., 41-800 Zabrze, Poland.ORCID 0000-0002-7551-9371

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Procalcitonin (PCT) is a precursor of calcitonin, and its determination is used in daily clinical practice. It is a good marker for bacterial infection and can help diagnose sepsis. In this review, we summarize recent findings on the utility of PCT serum concentration measurement in noninfectious conditions. We found that elevated PCT levels may help in diagnosing or monitoring the course of cancer or inflammatory diseases. An increase was observed in emergency care such as acute renal failure or injuries, which may be promising in estimating the risk of complications. PCT has the potential to become a useful and clinically relevant marker beyond the assessment of bacterial infection. Due to its limited specificity, therapeutic decisions should be based on an individual evaluation of each clinical case.

Indexed as

autoimmunological diseasescarcinomacirculating biomarkershepatotoxicityinflammationinjuryprocalcitoninrenal failuresurgery

Identifiers

PMID40141790
PMCPMC11944121

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.