Evidence map›Paper›PMID 40141795›Full record

ArticleLife (Basel, Switzerland)2025

Cerebral Inflammation in an Animal Ischemia-Reperfusion Model Comparing Histidine-Tryptophan-α-Ketoglutarate and Del Nido Cardioplegia.

Kristin Klaeske, Maja-Theresa Dieterlen, Jagdip Kang, Zoe Detzer, André Ginther, Susann Ossmann, Michael A Borger, Philipp Kiefer, Alexandro A Hoyer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristin KlaeskeDepartment of Cardiac Surgery, Helios Clinic, Heart Center Leipzig, Leipzig University, 04289 Leipzig, Germany.
Maja-Theresa DieterlenDepartment of Cardiac Surgery, Helios Clinic, Heart Center Leipzig, Leipzig University, 04289 Leipzig, Germany.ORCID 0000-0002-5503-9901
Jagdip KangDepartment of Cardiac Surgery, Helios Clinic, Heart Center Leipzig, Leipzig University, 04289 Leipzig, Germany.
Zoe DetzerDepartment of Cardiac Surgery, Helios Clinic, Heart Center Leipzig, Leipzig University, 04289 Leipzig, Germany.
André GintherDepartment of Cardiac Surgery, Helios Clinic, Heart Center Leipzig, Leipzig University, 04289 Leipzig, Germany.
Susann OssmannDepartment of Cardiac Surgery, Helios Clinic, Heart Center Leipzig, Leipzig University, 04289 Leipzig, Germany.ORCID 0000-0001-5218-3126
Michael A BorgerDepartment of Cardiac Surgery, Helios Clinic, Heart Center Leipzig, Leipzig University, 04289 Leipzig, Germany.ORCID 0000-0003-1046-1364
Philipp KieferDepartment of Cardiac Surgery, Helios Clinic, Heart Center Leipzig, Leipzig University, 04289 Leipzig, Germany.
Alexandro A HoyerDepartment of Cardiac Surgery, Helios Clinic, Heart Center Leipzig, Leipzig University, 04289 Leipzig, Germany.ORCID 0000-0003-1011-1495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain injury and cerebral inflammation are frequent complications following cardiopulmonary bypass (CPB) resulting in neurocognitive dysfunction, encephalopathy, or stroke. We compared cerebral inflammation induced by del Nido and histidine-tryptophan-α-ketoglutarate (HTK) cardioplegia in a porcine model. Pigs underwent 90 min cardiac arrest using HTK (n = 9) or Jonosteril

Indexed as

cardiopulmonary bypassCustodioldel Nidoorgan preservation

Identifiers

PMID40141795
PMCPMC11943810

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.