Evidence mapPaperPMID 40142259Full record

ReviewMedicina (Kaunas, Lithuania)2025

Comparing Early Intervention to Watchful Waiting: A Review on Risk Stratification and Management in Asymptomatic Aortic Stenosis.

Ahmed E Khedr, Nour B Odeh, George Bcharah, Hesham M Abdalla, Abdulrahman Senjab, Rawan M Zeineddine, Jaikrishnan Ram, Juan M Farina, Owen R Crystal, Bryan Barrus and 6 more

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ahmed E KhedrDepartment of Cardiothoracic Surgery, Mayo Clinic, Phoenix, AZ 85054, USA.ORCID 0000-0002-6464-4425
Nour B OdehDepartment of Cardiothoracic Surgery, Mayo Clinic, Phoenix, AZ 85054, USA.
George BcharahDepartment of Cardiothoracic Surgery, Mayo Clinic Alix School of Medicine, Phoenix, AZ 85054, USA.ORCID 0009-0009-9296-2824
Hesham M AbdallaDepartment of Internal Medicine, Mayo Clinic, Phoenix, AZ 85054, USA.
Abdulrahman SenjabDepartment of Cardiothoracic Surgery, Mayo Clinic, Phoenix, AZ 85054, USA.ORCID 0009-0009-2219-9237
Rawan M ZeineddineDepartment of Cardiothoracic Surgery, Mayo Clinic, Phoenix, AZ 85054, USA.
Jaikrishnan RamDepartment of Cardiothoracic Surgery, Mayo Clinic Alix School of Medicine, Phoenix, AZ 85054, USA.
Juan M FarinaDepartment of Cardiothoracic Surgery, Mayo Clinic, Phoenix, AZ 85054, USA.ORCID 0000-0002-5824-8485
Owen R CrystalDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ 85054, USA.
Bryan BarrusDepartment of Cardiothoracic Surgery, Mayo Clinic, Phoenix, AZ 85054, USA.
Steven J LesterDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ 85054, USA.
Justin ShipmanDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ 85054, USA.
Said AlsidawiDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ 85054, USA.ORCID 0000-0001-8750-7880
Chadi AyoubDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ 85054, USA.
Kristen A Sell-DottinDepartment of Cardiothoracic Surgery, Mayo Clinic, Phoenix, AZ 85054, USA.ORCID 0000-0001-5933-3537
Reza ArsanjaniDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ 85054, USA.ORCID 0000-0001-7081-4286

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aortic stenosis is a progressive condition with substantial implications for morbidity and mortality. In recent years, attention has shifted toward risk stratification and the development of individualized management plans to optimize treatment outcomes. The management of asymptomatic patients has become a topic of significant controversy, as emerging studies challenge traditional watchful waiting guidelines and propose the potential benefits of early intervention. While early intervention may reduce overall morbidity and mortality in this patient population, the associated procedural risks remain a critical consideration. This review seeks to analyze the existing literature, offering an updated perspective on patient risk stratification and evidence evaluating both management approaches.

Indexed as

Aortic Valve StenosisEarly Medical InterventionWatchful WaitingAsymptomatic DiseasesHumansRisk Assessmentaortic valve replacementasymptomatic aortic stenosisclinical guidelinesclinical surveillanceinterventionrisk stratification

Identifiers

PMID40142259
PMCPMC11943529

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.