Evidence map›Paper›PMID 40142260›Full record

ReviewMedicina (Kaunas, Lithuania)2025

Comprehensive Insights into Sarcopenia in Dialysis Patients: Mechanisms, Assessment, and Therapeutic Approaches.

Mariateresa Zicarelli, Anila Duni, Konstantinos Leivaditis, Yu-Li Lin, Federica Baciga, Sara Pugliese, Marco Fiorentino, Bang-Gee Hsu, Stefanos Roumeliotis, Yuri Battaglia and 2 more

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mariateresa ZicarelliDepartment of Health Sciences, University "Magna-Graecia" of Catanzaro, 88100 Catanzaro, Italy.
Anila Duni2nd Department of Nephrology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Konstantinos Leivaditis2nd Department of Nephrology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Yu-Li LinDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.ORCID 0000-0001-9094-0589
Federica BacigaDepartment of Medicine, University of Verona, 37129 Verona, Italy.
Sara PuglieseSchool of Medicine, University "Magna-Graecia" of Catanzaro, 88100 Catanzaro, Italy.
Marco FiorentinoNephrology, Dialysis and Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, 70121 Bari, Italy.ORCID 0000-0001-7334-8372
Bang-Gee HsuDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.ORCID 0000-0001-9364-4558
Stefanos Roumeliotis2nd Department of Nephrology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-9423-649X
Yuri BattagliaDepartment of Medicine, University of Verona, 37129 Verona, Italy.ORCID 0000-0003-3947-1814
Evangelia Dounousi2nd Department of Nephrology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-1172-1829
Davide BolignanoDepartment of Medical and Surgical Sciences, University "Magna-Graecia" of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0003-3032-245X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcopenia, defined as the progressive loss of muscle mass, strength, and function, is largely prevalent but still clinically underrecognized among patients undergoing chronic dialysis therapy. The pathogenesis involves a complex interplay of chronic inflammation, oxidative stress, metabolic acidosis, hormonal imbalances, protein waste, malnutrition, and reduced physical activity. This multifactorial condition profoundly impairs quality of life and may lead to significant clinical consequences, including frailty, an increased risk of falls and hospitalization, and elevated mortality. Despite its clinical relevance, sarcopenia often remains underdiagnosed due to inconsistent diagnostic criteria and challenges in assessing body composition in dialysis populations. Therapeutic strategies, including tailored exercise programs, nutritional interventions, and pharmacological treatments, are essential to mitigate muscle loss and improve patient outcomes. Early identification and routine sarcopenia assessment in clinical practice could play a pivotal role in enhancing the management of dialysis patients. A multidisciplinary, personalized approach is necessary to address the diverse factors contributing to sarcopenia and to improve the overall prognosis and quality of life for this vulnerable population.

Indexed as

Renal DialysisSarcopeniaHumansQuality of Lifeend-stage kidney diseasehemodialysisperitoneal dialysissarcopenia

Identifiers

PMID40142260
PMCPMC11944051

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.