Evidence map›Paper›PMID 40143237›Full record

ArticleViruses2025

Transcriptional Upregulation of HERV-

Seyedesomaye Jasemi, Elena Rita Simula, Antonella Pantaleo, Leonardo A Sechi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Seyedesomaye JasemiDepartment of Biomedical Sciences, Division of Microbiology and Virology, University of Sassari, 07100 Sassari, Italy.
Elena Rita SimulaDepartment of Biomedical Sciences, Division of Microbiology and Virology, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-8946-2679
Antonella PantaleoDepartment of Biomedical Sciences, Division of Microbiology and Virology, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0003-2954-7053
Leonardo A SechiDepartment of Biomedical Sciences, Division of Microbiology and Virology, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0003-0566-2049

Funding

European Union e.INS Ecosystem of Innovation for Next Generation SardiniaMUR, PRIN 2022 n: 2022BP837R to LASRegione Autonoma Sardegna legge regionale 12 22 December 2022 n. 22 to LAS
6 · The paper itself

Abstract

Human endogenous retroviruses (HERVs) constitute about 8% of the human genome. The overexpression of HERVs has been detected in various inflammatory disorders like neuro-inflammation disorders and cancer. Interestingly, it has been reported that stress conditions facilitate HERV expression. Space travel exposes astronauts to microgravity environments (a stress condition), which may result in the activation of HERVs and might influence pathogenic outcomes during and after space flight. This study aimed to elucidate the transcriptional activity of three HERV families (W, K, and H) and cytokine genes (

Indexed as

Endogenous RetrovirusesGene Products, envGenes, envUp-RegulationWeightlessnessWeightlessness SimulationCaco-2 CellsCell LineCell Line, TumorCytokinesGene Expression Regulation, ViralHumansInterleukin-6Tumor Necrosis Factor-alphaCytokinesGene Products, envInterleukin-6Tumor Necrosis Factor-alphacytokine expression genesHERV gene expressionmicrogravity simulation

Identifiers

PMID40143237
PMCPMC11945878

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.