Evidence map›Paper›PMID 40143251›Full record

ArticleViruses2025

Covariation of Amino Acid Substitutions in the HIV-1 Envelope Glycoprotein gp120 and the Antisense Protein ASP Associated with Coreceptor Usage.

Angelo Pavesi, Fabio Romerio

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Angelo PavesiDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 23A, I-43124 Parma, Italy.
Fabio RomerioDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA.ORCID 0000-0002-2070-297X

Funding

Sustained HIV Remission via Sequence-Specific Epigenetic Silencing of Latent ProvirusesR01AI144983 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ROMERIO, FABIO · 2019 to 2024
$3.6M
NIAID NIH HHS R01 AI144983NIH HHS AI172556
6 · The paper itself

Abstract

The tropism of the Human Immunodeficiency Virus type 1 (HIV-1) is determined by the use of either or both chemokine coreceptors CCR5 (R5) and CXCR4 (X4) for entry into the target cell. The ability of HIV-1 to bind R5 or X4 is determined primarily by the third variable loop (V3) of the viral envelope glycoprotein gp120. HIV-1 strains of pandemic group M contain an antisense gene termed

Indexed as

Amino Acid SubstitutionHIV-1HIV Envelope Protein gp120Receptors, HIVViral TropismHIV InfectionsHumansReceptors, CCR5Receptors, CXCR4Virus InternalizationCCR5 protein, humanCXCR4 protein, humangp120 protein, Human immunodeficiency virus 1HIV Envelope Protein gp120Receptors, CCR5Receptors, CXCR4Receptors, HIVantisense gene aspcell tropismcoevolutioncoreceptor usageenvelope proteinFisher’s linear discriminant analysisHIV-1prediction algorithm

Identifiers

PMID40143251
PMCPMC11946160

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.