Evidence map›Paper›PMID 40143276›Full record

ArticleViruses2025

Evaluation of Celastrol Antiviral Activity Against Equid Alphaherpesvirus Type 8 Infection.

Yue Yu, Jiayu Wang, Lian Ruan, Li Chen, Muhammad Zahoor Khan, Anrong You, Changfa Wang, Liangliang Li, Huiying Ren, Tongtong Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yue YuCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.
Jiayu WangCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.
Lian RuanLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng 252000, China.
Li ChenLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng 252000, China.
Muhammad Zahoor KhanLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng 252000, China.ORCID 0000-0001-5890-2996
Anrong YouLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng 252000, China.
Changfa WangLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng 252000, China.ORCID 0000-0002-5186-1703
Liangliang LiLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng 252000, China.
Huiying RenCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.
Tongtong WangLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng 252000, China.
Wenhua LiuCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China.

Funding

he Innovation and Entrepreneurship Program for College Students CXCY2022434Natural Science Foundation of Shandong Province ZR2024MC16Project of Shandong Province Higher Educational Science and Technology Program for Youth 2022KJ287Shandong Province Modern Agricultural Technology System Donkey Industrial Innovation Team SDAIT-27, SDAIT-27-04,SDAIT-27-17
6 · The paper itself

Abstract

Equid alphaherpesvirus type 8 (EHV-8) is a contagious pathogen that causes reproductive disorders, respiratory diseases, and viral encephalitis in equids, resulting in significant economic losses for the global horse and donkey industries. Currently, there are no approved antiviral drugs or vaccines available for EHV-8 control. In this study, we investigated the antiviral efficacy of celastrol against EHV-8 both in vitro and in vivo. Our results demonstrated that celastrol significantly inhibited EHV-8 infection in Rabbit kidney (RK-13) and equine dermal cells (NBL-6) in a dose-dependent manner. Mechanistic studies revealed that celastrol interfered with viral replication at multiple stages of the infection cycle. Furthermore, we found that celastrol induced an antiviral interferon response through activation of the Nrf2/HO-1 signaling pathway. Importantly, celastrol treatment significantly reduced EHV-8 replication and ameliorated lung pathology in a mouse model. These findings suggest that celastrol may represent a promising therapeutic agent for the treatment of EHV-8 infections.

Indexed as

Antiviral AgentsHerpesviridae InfectionsHorse DiseasesTriterpenesVaricellovirusAnimalsCell LineDisease Models, AnimalHorsesLungMicePentacyclic TriterpenesRabbitsVirus ReplicationAntiviral AgentscelastrolPentacyclic TriterpenesTriterpenesantiviral therapeuticscelastrolEHV-8Nrf2/HO-1

Identifiers

PMID40143276
PMCPMC11945448

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.