Evidence map›Paper›PMID 40143721›Full record

ArticlePsychiatry investigation2025

Relationship Between Brain-Derived Neurotrophic Factor and Cognitive Function in Methamphetamine-Dependent Patients.

Hwallip Bae, Sung-Doo Won, Jiyoun Kim, Hye-Jin Seo, Changwoo Han

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PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hwallip BaeDepartment of Psychiatry, National Medical Center, Seoul, Republic of Korea.
Sung-Doo WonDepartment of Psychology, Daegu Catholic University, Daegu, Republic of Korea.
Jiyoun KimDepartment of Addiction, Catholic University, Seoul, Republic of Korea.
Hye-Jin SeoDepartment of Psychiatry, Yongin Mental Hospital, Yongin, Republic of Korea.
Changwoo HanDepartment of Psychiatry, Myongji Hospital, Hanyang University, Goyang, Republic of Korea.

Funding

Ministry of EducationNational Research Foundation of Korea 2018R1D1A1B07047505
6 · The paper itself

Abstract

objectiveMethamphetamine (METH) is a neurotoxic substance that can induce neurodegeneration in the human brain. Consequently chronic METH use can affect the cognitive functions in METH-dependent patients. In this study, we aimed to identify the relationship between cognitive function and brain-derived neurotrophic factor (BDNF), which reflects the status of neuroadaptive changes, by characterizing the effects on the cognitive function of METH-dependent patients.

methodsA total of 38 METH-dependent patients participated in this study. BDNF levels were measured using the enzyme-linked immunosorbent assay. We also examined the clinical features based on the measurements of the Consortium to Establish a Registry for Alzheimer's Disease-Korean version (CERAD-K). Finally, the relationships between various parts of CERAD-K and BDNF were compared with one another.

resultsMETH-dependent patients were able to conduct most parts of CERAD-K stably. Among the parts of CERAD-K, only trail-making test part B was correlated with BDNF.

conclusionThe trail-making test is specific for evaluating executive function; therefore, BDNF may play an essential role in detecting neurocognitive functional decline in METH dependence.

Indexed as

Brain-derived neurotrophic factor.Cognitive functionMethamphetamine dependence

Identifiers

PMID40143721
PMCPMC11962524

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.