ArticleCureus2025
Development and Validation of a Neuro-Intensive Care Protocol for Traumatic Brain Injury Management.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Traumatic brain injury (TBI) is a global public health concern with high mortality and disability rates, particularly among younger populations. Structured treatment protocols might improve outcomes and reduce mortality. This study aims to develop and validate the Neuro-Intensive Care Protocol for TBI (NICP-TBI) using the Medical Research Council framework for designing and evaluating complex interventions. Methods The protocol was developed using a systematic literature review, expert consensus, and validation. A 15-member multidisciplinary expert consensus group used the Delphi consensus method to refine the protocol, achieving a consensus threshold of 80%. Validation involved a seven-member expert group evaluating the protocol's relevance, clarity, comprehensiveness, and appropriateness using a five-point Likert scale. The Content Validity Index (CVI) was calculated. Results The NICP-TBI incorporated interventions from clinical practice guidelines and evidence-based protocols. It established clear treatment goals and interventions for each parameter concerned such as airway, ventilation, systemic and cerebral perfusion, intracranial pressure (ICP), sedation, seizure prophylaxis, fluid management, nutrition, infection prophylaxis, temperature management, venous thromboembolism (VTE), blood glucose management, positioning, tapering treatment and family involvement in care. The protocol used a tiered structure adaptable to resource-limited settings. The Delphi process reached a 99.2% final consensus after five rounds, and the CVI was determined to be 1, confirming high validity. Conclusions The NICP-TBI provides a structured, evidence-based framework for managing moderate and severe TBI. The protocol's consensus-driven development, tiered approach in management, and expert validation ensure its applicability across diverse clinical settings, including resource-limited environments. This study highlights the importance of expert consensus and validation in developing effective critical care protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.