Evidence map›Paper›PMID 40144452›Full record

ArticleCurrent research in toxicology2025

Developmental polychlorinated biphenyl (PCB) exposure impacts on voiding physiology persist into adulthood and influence sensitivity to bladder stimuli in mice.

Monica Ridlon, Audrey Spiegelhoff, Conner L Kennedy, Thomas Lavery, Kathy Wang, Julia Tlapa, Tamryn Jordan, Lindsey Felth Tanaka, Kimberly Keil Stietz

Abstract read
In one paragraph

Article in Current research in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Monica RidlonDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI, USA.
Audrey SpiegelhoffDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI, USA.
Conner L KennedyDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI, USA.
Thomas LaveryDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI, USA.
Kathy WangDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI, USA.
Julia TlapaDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI, USA.
Tamryn JordanDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI, USA.
Lindsey Felth TanakaDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI, USA.
Kimberly Keil StietzDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI, USA.

Funding

Training CoreP42ES013661 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 2006 to 2026
$60.3M
Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RICKE, WILLIAM A · 2014 to 2023
$12.8M
Molecular & Environmental Toxicology Pre-& Postdoctoral Training ProgramT32ES007015 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD · 1985 to 2026
$11.5M
Stanford O'Brien Urology Research CenterU54DK130065 · NIDDK · STANFORD UNIVERSITY · PI JAMES D. BROOKS · 2021 to 2026
$8.3M
Impact of developmental polychlorinated biphenyls on bladder contractilityR01ES035020 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI Kimberly Preston Keil Stietz · 2024 to 2026
$1.1M
PCB induced neurogenic inflammation mediates bladder dysfunctionR00ES029537 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI STIETZ, KIMBERLY PRESTON KEIL · 2020 to 2023
$747k
Contribution of obesity-environment interaction in bladder dysfunctionR03ES033304 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI STIETZ, KIMBERLY PRESTON KEIL · 2022 to 2023
$156k
NIDDK NIH HHS U54 DK104310NIDDK NIH HHS U54 DK130065NIEHS NIH HHS P42 ES013661NIEHS NIH HHS R00 ES029537NIEHS NIH HHS R01 ES035020NIEHS NIH HHS R03 ES033304NIEHS NIH HHS T32 ES007015
6 · The paper itself

Abstract

Polychlorinated biphenyls (PCBs) are toxicants present in the environment, foodstuff, animal and human tissues. PCBs are linked to numerous adverse health effects; however, impacts of developmental PCB exposure on lower urinary tract function are a comparatively newer area of interest. We have previously found developmental exposure (

Indexed as

CapsaicinCystometryDevelopmental and reproductive toxicologyLower urinary tractMARBLES PCBTRPV1

Identifiers

PMID40144452
PMCPMC11937689

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.