Evidence map›Paper›PMID 40144719›Full record

ArticleJHLT open2025

Evaluation of target temperature on effectiveness of myocardial preservation during hypothermic machine perfusion.

Guilherme Mainardi Aguiar da Silva, Mitchell J Wagner, Sanaz Hatami, Parham Hassanzadeh, Xiuhua Wang, Benjamin A Adam, Jayan Nagendran, Darren H Freed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHLT open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guilherme Mainardi Aguiar da SilvaDepartment of Surgery, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Mitchell J WagnerDepartment of Surgery, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Sanaz HatamiDepartment of Surgery, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Parham HassanzadehDepartment of Surgery, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Xiuhua WangDepartment of Surgery, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Benjamin A AdamDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Jayan NagendranDivision of Cardiac Surgery, Department of Surgery, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Darren H FreedDivision of Cardiac Surgery, Department of Surgery, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ex-situ heart perfusion (ESHP) has been proposed as an optimal method for preserving donated hearts prior to transplantation. Hypothermic oxygenated perfusion (HOP) is a simple method from a device design perspective, with enhanced safety compared to normothermic perfusion in the event of device failure. However, the optimal temperature for cardiac HOP has yet to be determined. We evaluated the effectiveness of 12-hour HOP using University of Wisconsin Machine Perfusion Solution (UWMPS) in different temperatures compared to static cold storage (SCS) for 6 hours followed by simulated transplantation. Additionally, we sought to determine the impact of oxygen supplementation in hypothermic ESHP in the heart function preservation. Methods: Hearts were procured from Yorkshire pigs ( Results: All perfusion parameters were stable throughout (mean ± SD): aortic flow 65 ± 5.57 ml/min, aortic pressure: 11.51 ± 3.17 mm Hg. All HOP hearts presented a better cardiac index than SCS ( Conclusions: HOP for 12 hours had better heart function preservation than SCS for 6 hours. Even HNOP had similar results compared to SCS. Greater edema formation in ESHP hearts did not affect heart function. Hypothermic ESHP safely enhances function preservation compared to SCS.

Indexed as

ex-situ heart perfusionheart transplantationhypothermic machine perfusionmyocardial preservationorgan preservation

Identifiers

PMID40144719
PMCPMC11935436

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.