Severe insulin-deficient diabetes is at the opposite end of the neuropathy spectrum to mild aged-related diabetes.
Brian C Callaghan, Ranjit Mohan Anjana, Lavanya Muthukumar, Evan L Reynolds, Jebarani Saravanan, Mani Arun Vignesh, Aswin Mukundan, Eva L Feldman, Viswanathan Mohan
Article in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Ranjit Mohan AnjanaMadras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Chennai, India.
Lavanya MuthukumarDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Evan L ReynoldsDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, USA.
Jebarani SaravananMadras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Chennai, India.
Mani Arun VigneshMadras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Chennai, India.
Aswin MukundanMadras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Chennai, India.
Eva L FeldmanDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Viswanathan MohanMadras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Chennai, India.
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Schwann Cell Senescence and the Secretome Provide a Unifying Mechanism for the Onset and Progression of Diabetic NeuropathyR01DK130913 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eva Lucille Feldman, Junguk Hur · 2022 to 2026
$3.3M
The Effect of High Intensity Interval Training and Surgical Weight Loss On Distal Symmetric Polyneuropathy OutcomesR01DK115687 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CALLAGHAN, BRIAN CHRISTOPHER · 2018 to 2022
$3.1M
Targeting Inflammation with Salsalate as a Novel Therapy for Diabetic NeuropathyR01DK107956 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUSUI (POP-BUSUI), RODICA, FELDMAN, EVA LUCILLE · 2016 to 2020
$3.0M
Identifying lifelong factors that impact brain health and outcomes in type 1 diabetes: The Cognition and Longitudinal Assessments of Risk Factors over 30 Years (CLARiFY) Diabetes Complications StudyR01DK129320 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FELDMAN, EVA LUCILLE · 2021 to 2025
$2.3M
Predicting complications of diabetes with longitudinal metabolic trajectoriesR00DK129785 · NIDDK · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI Evan L Reynolds · 2024 to 2026
The effect of diabetes subtypes on neuropathy prevalence and metabolic drivers of this relationship are unknown. Using electronic medical records from 50 diabetes care centers in eight states of India with biothesiometer and complete phenotyping data on 22,348 patients, we determined neuropathy prevalence stratified by India-specific diabetes subtypes and evaluated associations with neuropathy (biothesiometer). Neuropathy prevalence was highest in severe insulin-deficient diabetes (SIDD; 25.5%), followed by insulin-resistant obese diabetes (IROD; 21.8%), mild age-related diabetes (MARD; 18.9%), and combined insulin-resistant and deficient diabetes (CIRDD; 17.3%, P = <0.001). HbA1c (odds ratio [OR]: 1.19, 1.16-1.21), diabetes duration (OR: 1.04, 1.04-1.05), and waist circumference (OR: 1.01, 1.01-1.02) were associated with neuropathy. SIDD (OR: 2.23, 2.01-2.47), CIRDD (OR: 1.89, 1.69-2.11), and IROD (OR: 1.84, 1.66-2.04) had increased neuropathy compared to MARD. In India, SIDD patients are more likely to have neuropathy compared to MARD patients likely from longer diabetes duration and higher HbA1c; therefore, interventions should focus on hyperglycemia. Interventions in CIRDD and IROD patients should likely address obesity as well.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.