Influence and molecular mechanism of cinnamaldehyde against ventricular arrhythmia via the TAK1-p38MAPK-NLRP3 pathway.

Guoping Ma, Mian Li, Wanyue Yang, Hai Wang, Xue Tian, Yajuan Yin, Yida Tang, Wenjie Liang

Abstract read

In one paragraph

Article in Heart and vessels, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Research progress on targeting autophagy pathways with medicinal plants and their active metabolites for the treatment of heart failure.Frontiers in pharmacology · 2026
Review

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guoping Ma *The First Hospital of Hebei Medical University, Shijiazhuang, 050031, China.

Mian Li *The First Hospital of Hebei Medical University, Shijiazhuang, 050031, China.

Wanyue YangThe First Hospital of Hebei Medical University, Shijiazhuang, 050031, China.

Hai WangThe First Hospital of Hebei Medical University, Shijiazhuang, 050031, China.

Xue TianThe First Hospital of Hebei Medical University, Shijiazhuang, 050031, China.

Yajuan YinThe First Hospital of Hebei Medical University, Shijiazhuang, 050031, China.

Yida TangThe First Hospital of Hebei Medical University, Shijiazhuang, 050031, China. 57303411@hebmu.edu.cn.

Wenjie LiangHebei University of Chinese Medicine, Shijiazhuang, 050200, China. lwj712004@126.com.ORCID http://orcid.org/0000-0002-7655-2122

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on the transforming growth factor β-activated kinase 1 (TAK1)-p38 mitogen-activated protein kinase (p38MAPK)-nucleotide-binding oligo-like receptor protein 3 (NLRP3) signalling pathway, the protective effect and mechanism of isoproterennaline (ISO)-induced cinnamaldehyde on inflammatory injury in ventricular rats were investigated. Fifty male SPF SD rats were randomly assigned to the normal group, model group, propranolol group, cinnamaldehyde low-dose group or cinnamaldehyde high-dose group. The ventricular arrhythmia model was constructed using the "6 + 1" ISO injection method. The rats in the propranolol group were given propranolol 15 mg·(kg d)

Indexed as

AcroleinArrhythmias, CardiacMAP Kinase Kinase KinasesNLR Family, Pyrin Domain-Containing 3 Proteinp38 Mitogen-Activated Protein KinasesAnimalsDisease Models, AnimalInterleukin-1betaMaleMAP Kinase Kinase Kinase 7RatsRats, Sprague-DawleyReactive Oxygen SpeciesSignal TransductionAcroleincinnamaldehydeInterleukin-1betaMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratp38 Mitogen-Activated Protein KinasesReactive Oxygen SpeciesCinnamaldehydeNucleotide binding oligomeric domain-like receptor protein 3P38 mitogen-activated protein kinaseTransforming growth factor-β activated kinase 1Ventricular arrhythmia

Identifiers

PMID40146271

DOI10.1007/s00380-025-02529-3

PMCPMC12380895

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.