Evidence map›Paper›PMID 40147776›Full record

ArticleThe Journal of biological chemistry2025

Unstructured protein domains stabilize RNA binding and mediate RNA folding by AUF1.

Nina C Lee, Haley H Tilley, Grace A Acle, Patrick J McGinnis, Gerald M Wilson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nina C LeeDepartment of Biochemistry and Molecular Biology, Center for Biomolecular Therapeutics, and Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Haley H TilleyDepartment of Biochemistry and Molecular Biology, Center for Biomolecular Therapeutics, and Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Grace A AcleDepartment of Biochemistry and Molecular Biology, Center for Biomolecular Therapeutics, and Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Patrick J McGinnisDepartment of Biochemistry and Molecular Biology, Center for Biomolecular Therapeutics, and Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Gerald M WilsonDepartment of Biochemistry and Molecular Biology, Center for Biomolecular Therapeutics, and Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA. Electronic address: gwilson@som.umaryland.edu.

Funding

Vascular Biology Training ProgramT32HL007698 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Rosemary A Kozar, Dudley K. Strickland · 1991 to 2026
$8.7M
The Nathan Schnaper Intern Program in Translational Cancer ResearchR25CA186872 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI BRET A HASSEL, Ian Robert Kleckner · 2015 to 2026
$3.0M
NCI NIH HHS R25 CA186872NHLBI NIH HHS T32 HL007698
6 · The paper itself

Abstract

AUF1 is an RNA-binding protein that targets AU-rich elements, cis-acting regulatory sequences commonly enriched in mRNAs encoding inflammatory mediators and oncoproteins. AUF1 post-transcriptionally regulates gene expression by modulating the stability and/or translational efficiency of mRNA targets in a context-specific manner; however, the mechanisms by which AUF1 directly engages RNA substrates and mediates regulatory outcomes remain largely unknown. The purpose of this study was to define the biochemical basis for RNA recognition by AUF1 using the smallest protein isoform (p37

Indexed as

Heterogeneous-Nuclear Ribonucleoprotein DRNARNA FoldingAU Rich ElementsHeterogeneous Nuclear Ribonucleoprotein D0HumansProtein BindingProtein DomainsRNA-Binding ProteinsHeterogeneous-Nuclear Ribonucleoprotein DHeterogeneous Nuclear Ribonucleoprotein D0HNRNPD protein, humanRNARNA-Binding ProteinsAU-rich elementAU-rich element RNA-binding protein 1 (AUF1)fluorescence anisotropyfluorescence resonance energy transfer (FRET)RNA binding proteinRNA foldingthermodynamics

Identifiers

PMID40147776
PMCPMC12147176

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.