Evidence map›Paper›PMID 40148080›Full record

SynthesisRenal failure2025

Physical activity interventions in adult kidney transplant recipients: an updated systematic review and meta-analysis of randomized controlled trials.

Roseanne E Billany, Nicolette C Bishop, Ellen M Castle, Matthew P M Graham-Brown, Sharlene A Greenwood, Courtney J Lightfoot, Thomas J Wilkinson

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07740928 (6-Week Mediterranean Diet Intervention on Dietary Adherence, Body Composition, and Physical Function in Kidney Transplant Recipients), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07740928 nacompletednot on this map

6-Week Mediterranean Diet Intervention on Dietary Adherence, Body Composition, and Physical Function in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorUniversity Medical Centre LjubljanaRan2023 to 2024Enrolled23ConditionsKidney Transplant Donor, Diet HabitArmsMedDiet
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Roseanne E BillanyDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Nicolette C BishopSchool of Sport, Exercise, and Health Sciences, Loughborough University, Loughborough, UK.
Ellen M CastleFaculty of Health Sciences, Curtin School of Allied Health, Curtin University, Perth, Australia.
Matthew P M Graham-BrownDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Sharlene A GreenwoodDepartment of Renal Medicine, King's College Hospital NHS Trust, London, UK.
Courtney J LightfootNIHR Leicester Biomedical Research Centre, Leicester, UK.
Thomas J WilkinsonNIHR Leicester Biomedical Research Centre, Leicester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney transplant recipients (KTRs) exhibit a high prevalence of cardiovascular disease (CVD) and adverse changes in physical fitness and body composition. Post-transplant management recommends being physically active and evidence in this field is growing. The aim of this review was to update our previous systematic review and meta-analysis of randomized controlled trials (RCTs) assessing the effects of physical activity and exercise training interventions in KTRs.

methodsA comprehensive literature search between March 2021 and September 2024 identified seven additional RCTs. Therefore, this updated review and meta-analysis includes 23 RCTs. Outcomes included cardiorespiratory fitness (CRF), strength, blood pressure, body composition, heart rate, markers of dyslipidemia and kidney function, and health-related quality of life.

resultsTwenty-three RCTs, including 1,139 KTRs, were included. The median intervention length was 12 weeks with participants exercising between 2 and 7×/week. Most studies used a mixture of aerobic and resistance training but reporting and intervention content was highly varied. Significant improvements were observed in CRF (V̇O

conclusionsExercise training or increasing physical activity may confer several benefits in adult KTRs, especially through the improvements in CRF and HDL which have been linked to CVD risk. Despite new literature, there is still a need for long-term larger sampled RCTs and more detailed reporting of intervention details and program adherence.

Indexed as

Cardiovascular DiseasesExerciseExercise TherapyKidney TransplantationTransplant RecipientsAdultCardiorespiratory FitnessHumansQuality of LifeRandomized Controlled Trials as Topiccardiovascular diseaseexerciseKidney transplantrehabilitationtraining

Identifiers

PMID40148080
PMCPMC11951324

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.