Evidence map›Paper›PMID 40148710›Full record

Trial reportEuropean journal of epidemiology2025

Effects of salt substitution on cumulative blood pressure: a secondary analysis of the SSaSS.

Xiaoxia Li, Liping Huang, Bo Zhou, Zhifang Li, Jixin Sun, Yan Yu, Hongyi Song, Maoyi Tian, Xuejun Yin, Bruce Neal and 3 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. How Does Dietary Potassium Influence BP?Journal of the American Society of Nephrology : JASN · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaoxia Li *School of Public Health, Ningxia Medical University, 1160 Shengli Street, Xingqing District, Yinchuan, China.
Liping Huang *The George Institute for Global Health, University of New South Wales, Sydney, Australia.
Bo ZhouDepartment of Evidence Based Medicine, First Hospital of China Medical University, Shenyang, 110000, China.
Zhifang LiSchool of Public Health, Changzhi Medical College, Changzhi, China.
Jixin SunDepartment of Noncommunicable Disease Prevention and Control, Center for Disease Control of Hebei Province, Shijiazhuang, China.
Yan YuSchool of Public Health, Xi'an Jiaotong University School of Medicine, Xi'an, China.
Hongyi SongThe George Institute for Global Health, Beijing, China.
Maoyi TianThe George Institute for Global Health, University of New South Wales, Sydney, Australia.
Xuejun YinSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Bruce NealThe George Institute for Global Health, University of New South Wales, Sydney, Australia.
Yuhong ZhangSchool of Public Health, Ningxia Medical University, 1160 Shengli Street, Xingqing District, Yinchuan, China. zhabour@163.com.
Yangfeng WuDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing, China.
Yi ZhaoSchool of Public Health, Ningxia Medical University, 1160 Shengli Street, Xingqing District, Yinchuan, China. 20040017@nxmu.edu.cn.

Funding

Australian National Health and Medical Research Council APP 1049417, and APP1164206
6 · The paper itself

Abstract

The effect of a potassium-enriched salt substitute on cumulative blood pressure (BP) remains unclear. This study aimed to assess the long-term effects of a potassium-enriched salt substitute versus regular salt on cumulative and conventional measures of systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP). We analyzed data from the Salt Substitute and Stroke Study (SSaSS), a 5-year cluster randomized controlled trial in rural of China with 20,995 participants. The intervention used salt substitute; controls used regular salt. BP was measured for all participants at baseline, among subsamples at 12-month intervals, and for all alive at 60 months. Cumulative BP was calculated as the average between baseline and follow-up measures multiplied by the time between them (mmHg × year). Linear mixed models were used to assess the effects of salt substitution on BP outcomes at each follow-up visit. After a mean 4.74 years of follow-up, salt substitute compared to the regular salt lowered the cumulative SBP with a mean (SD) of 740 (85) vs. 750 (87) mmHg×year. Salt substitute also lowered cumulative MAP and PP, with means (SD) of 560 (58) vs. 566 (59) mmHg×year, and 306 (67) vs. 313 (68) mmHg×year, respectively. Similar beneficial effects of the salt substitute were observed for traditional measurements of SBP, MAP, and PP. There was no difference in either cumulative DBP (434 vs. 437 mmHg × year) or traditional DBP (85 vs. 86 mmHg). Salt substitute significantly reduced cumulative and traditional SBP, MAP, and PP, but not DBP.

trial registrationSSaSS ClinicalTrials.gov number: NCT0 2,092,090.

Indexed as

Blood PressureHypertensionPotassiumSodium Chloride, DietaryAdultAgedChinaFemaleHumansMaleMiddle AgedPotassiumSodium Chloride, DietaryCumulative blood pressureMean arterial pressurePulse pressureSalt substitute

Identifiers

PMID40148710

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.