Evidence map›Paper›PMID 40148898›Full record

ArticleDiabetology & metabolic syndrome2025

High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes.

Hanying Wang, Liping Gu, Yuhang Ma, Xindan Xing, Yuan Qu, Xin Shi, Xinyi Liu, Hancong Wan, Qian Zhu, Yingchen Shen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hanying Wang *Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, No. 100 Haining Road, Shanghai, 20080, P. R. China.
Liping Gu *Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Yuhang Ma *Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Xindan XingDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, No. 100 Haining Road, Shanghai, 20080, P. R. China.
Yuan QuDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, No. 100 Haining Road, Shanghai, 20080, P. R. China.
Xin ShiDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, No. 100 Haining Road, Shanghai, 20080, P. R. China.
Xinyi LiuDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, No. 100 Haining Road, Shanghai, 20080, P. R. China.
Hancong WanDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, No. 100 Haining Road, Shanghai, 20080, P. R. China.
Qian ZhuDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, No. 100 Haining Road, Shanghai, 20080, P. R. China.
Yingchen ShenDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, No. 100 Haining Road, Shanghai, 20080, P. R. China.
Chong ChenDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, No. 100 Haining Road, Shanghai, 20080, P. R. China.
Li SuDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, No. 100 Haining Road, Shanghai, 20080, P. R. China.
Yufan WangDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. yyffwang@sina.com.
Kun LiuDepartment of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, No. 100 Haining Road, Shanghai, 20080, P. R. China. drliukun@sjtu.edu.cn.

Funding

National Natural Science Foundation of China 82171071Program of Shanghai Academic Research Leader 21XD1402700
6 · The paper itself

Abstract

aimsTo assess the association between serum uric acid (SUA) level and the prevalence of diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with long-term diabetes.

methodsA cross-sectional analysis was conducted involving diabetic patients from Shanghai General hospital during October 2018 and October 2021. Participants underwent measurements of SUA, renal function test and DR assessments via fundus photography. Multivariable ordinal logistic regression models assessed odd ratios (ORs) and 95% confidence intervals (95% CIs) for the progression of DR and CKD. Receiver operating characteristics (ROC) curves identified SUA thresholds, categorizing participants into low and high SUA groups.

resultsAmong the 1015 patients with diabetes, SUA levels were higher in individuals with advanced CKD stages (p < 0.001, compared with stage 1 CKD) and vision-threatening diabetic retinopathy (VTDR) (p = 0.019, compared with no diabetic retinopathy (NDR)). In multivariable models adjusted for potential confounders, higher SUA levels were associated with an increased risk of DR (OR: 1.002, 95% CI: 1.001-1.004) and CKD (OR: 1.008, 95% CI: 1.006-1.011). Notably, SUA levels exceeding 354.0 µmol/L (95% CI: 318.9-393.2) and 361.0 µmol/L (339.2-386.3) were associated with 1.571-fold (95% CI: 1.139-2.099, P = 0.006 for DR) and 1.395-fold (95% CI: 1.033-1.885, P = 0.030 for CKD) increased risks, respectively. Gender-specific analyses also demonstrated a positive correlation between higher SUA levels and the incidence of DR and CKD in both males and females.

conclusionsElevated SUA levels are independently coincided with increased risks of DR and CKD, suggesting that SUA may serve as a potential risk marker for diabetic complications.

Indexed as

Chronic kidney diseaseDiabetes mellitusDiabetic retinopathySerum uric acid

Identifiers

PMID40148898
PMCPMC11951721

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.