ArticleDiabetology & metabolic syndrome2025
Genetically predicted amino acids related to neural regulation mediate the association between diabetes mellitus and postherpetic neuralgia: a Mendelian randomization study.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Nomogram-Based Prediction Model for Postherpetic Neuralgia in Immunosuppressive Patients.Journal of clinical medicine · 2026Article
- Outcomes of Single versus Repeated High-Voltage Pulsed Radiofrequency for Thoracic Herpes Zoster Neuralgia in Patients with Diabetes Mellitus: A Retrospective Study.Journal of pain research · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundPostherpetic neuralgia (PHN) and diabetes mellitus frequently coexist in clinical settings; however, the causal relationship between them remains unclear. Moreover, the potential mediating role of amino acids related to neural regulation in this association has not been fully explored yet.
methodsUnivariable Mendelian randomized (UVMR) was utilized to examine the causal relationship between various subtypes of diabetes mellitus and PHN, with the inverse variance weighted method as the main approach. Multivariable MR (MVMR) was conducted to assess the direct effect of diabetes mellitus, accounting for waist circumference, diabetic neuropathy/ulcers, and depression. Moreover, a two-step MR analysis was employed to investigate the mediating role of neurotransmitter-related amino acids in the association between diabetes mellitus and PHN.
resultsA significant statistical correlation was found between type 2 diabetes mellitus (T2DM) and PHN (odds ratio, OR: 1.23, 95% confidence interval, CI: 1.01-1.49, P = 0.036), while in type 1 diabetes mellitus or pregnancy diabetes mellitus, no evidence of the association with PHN was observed. MVMR analyses demonstrated that the effect of T2DM on PHN remained significant after adjusting for waist circumference, diabetic neuropathy/ulcers, and depression. Further mediation analysis revealed that phenylalanine accounted for 49.2% (95% CI: 22.7- 75.6%) of the total effect of T2DM on PHN.
conclusionThe current study suggested that T2DM was associated with an increased risk of PHN, with phenylalanine playing a mediating role. These findings provided valuable insights for the screening and prevention of PHN in clinical practice.
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