Evidence map›Paper›PMID 40149457›Full record

ReviewGenes2025

Edoardo Genio, Mauro Lecca, Rachele Ciccocioppo, Edoardo Errichiello

Abstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Novel pathogenicFrontiers in immunology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Edoardo GenioUnit of Medical Genetics, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.
Mauro LeccaUnit of Medical Genetics, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0009-0004-0577-5259
Rachele CiccocioppoGastroenterology and Endoscopic Unit, Department of Medicine and Ageing, University Gabriele D'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-6297-7576
Edoardo ErrichielloUnit of Medical Genetics, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0001-6346-1988

Funding

Jeffrey Modell Foundation NA
6 · The paper itself

Abstract

Cytotoxic-T-lymphocyte-antigen-4 (CTLA-4), a member of the immunoglobulin superfamily, is an essential negative regulator of immune responses that is constitutively expressed on both regulatory (Treg) and activated T cells. To date, heterozygous germline variants in

Indexed as

CTLA-4 AntigenFemaleHumansMaleMutation, MissensePedigreePhenotypeCTLA-4 AntigenCTLA4 protein, humanautoimmunityCTLA4demyelinationhaploinsufficiencyimmunodeficiency

Identifiers

PMID40149457
PMCPMC11942126

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.