Evidence map›Paper›PMID 40149955›Full record

ArticleBiomolecules2025

The Role of Purinergic Mechanisms in the Excitability of Trigeminal Afferents of Rats with Prenatal Hyperhomocysteinemia.

Elizaveta Ermakova, Svetlana Svitko, Alsu Kabirova, Egor Nevsky, Olga Yakovleva, Karina Gilizhdinova, Kseniia Shaidullova, Anton Hermann, Guzel Sitdikova

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In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elizaveta ErmakovaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.ORCID 0000-0002-2045-5294
Svetlana SvitkoDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.ORCID 0009-0003-1507-6120
Alsu KabirovaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.
Egor NevskyDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.
Olga YakovlevaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.
Karina GilizhdinovaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.
Kseniia ShaidullovaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.
Anton HermannDepartment of Biosciences, University of Salzburg, Hellbrunnerstr. 34, 5020 Salzburg, Austria.
Guzel SitdikovaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlevskaya Str., 420008 Kazan, Russia.ORCID 0000-0001-5412-2204

Funding

Russian Science Foundation 20-15-00100
6 · The paper itself

Abstract

Elevated levels of homocysteine in the blood plasma (hyperhomocysteinemia, HHCY) positively correlate with migraine symptoms in patients. Experimental studies show a higher sensitivity of rats with prenatal HHCY (pHHCY) to migraine symptoms like allodynia, photophobia, anxiety, and a higher excitability of meningeal trigeminal afferents. In the present study, the roles of purinergic mechanisms in the homocysteine-induced hyperexcitability of the trigeminal ganglion (TG) system using electrophysiological recordings from the trigeminal nerve, Ca

Indexed as

HyperhomocysteinemiaReceptors, PurinergicTrigeminal GanglionTrigeminal NerveAdenosine TriphosphateAnimalsCalciumFemaleHomocysteineMast CellsMigraine DisordersPregnancyRatsAdenosine TriphosphateCalciumHomocysteineReceptors, Purinergiccalcitonin gene-related peptide (CGRP)homocysteinemast cellsmeningeal afferentsmigrainepurinergic receptorstrigeminal ganglion (TG) cells

Identifiers

PMID40149955
PMCPMC11940108

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.