Evidence mapPaperPMID 40150674Full record

ReviewChildren (Basel, Switzerland)2025

Vitamin D: What We Know and What We Still Do Not Know About Vitamin D in Preterm Infants-A Literature Review.

Ioana Andrada Radu, Maria Livia Ognean, Laura Ștef, Doina Ileana Giurgiu, Manuela Cucerea, Cristian Gheonea

Abstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ioana Andrada RaduDoctoral School, University of Medicine and Pharmacy, 200349 Craiova, Romania.ORCID 0009-0005-8179-6702
Maria Livia OgneanFaculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania.ORCID 0000-0002-2233-4218
Laura ȘtefFaculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania.
Doina Ileana GiurgiuFaculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania.ORCID 0000-0001-5232-7388
Manuela CucereaDepartment of Neonatology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.ORCID 0000-0003-2498-5433
Cristian GheoneaDepartment of Pediatrics, University of Medicine and Pharmacy, 200349 Craiova, Romania.ORCID 0009-0001-9234-6097

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesPreterm infants represent a population group at increased risk for vitamin D deficiency (VDD) and for its negative impact on various outcomes like metabolic bone disease or rickets, respiratory complications like respiratory distress syndrome and the development of bronchopulmonary dysplasia, necrotizing enterocolitis, or retinopathy of prematurity.

methodsDespite the growing interest in vitamin D research, there is still uncertainty regarding clear recommendations for each high-risk category of premature infants concerning the optimal dosage, optimal product, and timing for initiating vitamin D supplementation to prevent VDD.

resultsAn analysis of the literature suggests that early intervention for the optimal enteral supplementation of vitamin D is not only successful in achieving higher 25-hydroxi-vitamin D (25(OH)D) at one month but is also linked with improved outcomes.

conclusionsThe traditional concepts and current recommendations for assessing vitamin D status and optimal supplementation need to be revised. Since parenteral nutrition, fortified mothers' own milk, and special formula for preterm infants cannot provide adequate vitamin D levels, initiating oral supplementation soon after birth is essential to correct VDD in preterm infants.

Indexed as

25(OH)D levelsenteral supplementationpreterm infantsvitamin Dvitamin D deficiency

Identifiers

PMID40150674
PMCPMC11941677

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.