ArticleBioengineering (Basel, Switzerland)2025
Biorecognition-Based Nanodiagnostics: Maltotriose-Functionalized Magnetic Nanoparticles for Targeted Magnetic Resonance Imaging of Bacterial Infections.
Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Bacterial infections remain a global healthcare challenge, requiring precise diagnostic modalities to guide therapeutic interventions. Current molecular imaging agents predominantly detect nonspecific hemodynamic alterations and lack pathogen-specific targeting capabilities for magnetic resonance imaging (MRI). Leveraging the selective bacterial uptake of maltotriose via the maltodextrin transport pathway, we engineered maltotriose-functionalized magnetic nanoparticles (Malt-MNPs) as a novel MRI contrast agent. Basic physicochemical characterization confirmed the nanosystem's colloidal stability, biocompatibility, and superparamagnetism (saturation magnetization > 50 emu/g). In a rat bacterial infection model, intravenously administered Malt-MNPs selectively accumulated at infection sites, inducing a >50% MRI signal change within 24 h while exhibiting minimal off-target retention in sterile inflammatory lesions (<10% signal change). This specificity enabled clear MRI-based differentiation between bacterial infections and noninfectious inflammation. These findings provide a promising strategy for clinical translation in infection imaging and treatment.
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