Evidence map›Paper›PMID 40151113›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Effects of Huluan decotion on cyclophosphamide-induced autoimmune premature ovarian failure in murine models.

Feng Guiling, Zhou Xiaolin, Shen Chengwan, L I Panxiao, Abulizi Abudula

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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Feng GuilingCollege of Medicial science, Ningde Normal university, Ningde 352000, China.
Zhou XiaolinNanyang Medical College, Nanyang 473000, China.
Shen ChengwanCollege of Medicial science, Ningde Normal university, Ningde 352000, China.
L I PanxiaoDepartment of Intensive care, Ningde Normal College affiliated Ningde Hospital, Ningde 352000, China.
Abulizi AbudulaCollege of Medicial science, Ningde Normal university, Ningde 352000, China.

Funding

Fujian Natural Science Foundation Project: Study on Potential Protein Targets of Huluan Decotion in the Intervention of Premature Ovarian Failure 2021J011173Major Project Cultivation Plan Project of Ningde Normal University: the Effect of Huluan Decotion on the Decreased Ovarian Reserve Function Induced by Cyclophosphamide is Studied based on Forkhead box L2 2019ZDK06
6 · The paper itself

Abstract

objectivesTo investigate the therapeutic effect of Huluan decotion (, HLD) on cyclophosphamide-induced premature ovarian failure (POF) in mice and its regulatory mechanisms.

methodsFemale BALB/c mice were administered cyclophosphamide and administered received different doses of HLD for 28 d. Levels of sex hormone, such as estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) in the sera, were assessed using enzyme-linked immunosorbent assay (ELISA). Follicular structure variances were observed through hematoxylin and eosin (HE) staining, while Forkhead box L2 (FOXL2) expression were analyzed

resultsE2 levels decreased, and FSH and LH levels increased in POF model mice, but these trends were reversed with HLD or premarin administration, the expressions of WNT family member 4 (Wnt4), β-Catenin and FOXL2 were downregulated in POF model mice, whereas high expression levels were observed in control mice and other groups.

conclusionHLD effectively treats POF induced with cyclophosphamide in mice by enhancing expressions of Wnt4, β-Catenin and FOXL2.

Indexed as

Autoimmune DiseasesCyclophosphamideDrugs, Chinese HerbalPrimary Ovarian InsufficiencyAnimalsbeta CateninDisease Models, AnimalEstradiolFemaleFollicle Stimulating HormoneForkhead Box Protein L2HumansLuteinizing HormoneMiceMice, Inbred BALB Cbeta CateninCyclophosphamideDrugs, Chinese HerbalEstradiolFollicle Stimulating HormoneForkhead Box Protein L2Luteinizing Hormonebeta catenincyclophosphamideHuluan decotionprescriptionsprimary ovarian insufficiencysignal transductionwnt4 protein

Identifiers

PMID40151113
PMCPMC11955766

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.