Evidence map›Paper›PMID 40151944›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025

Relationship of Multiple Sensory Impairments With Physical Performance in Older Adults in the Study of Muscle, Mobility and Aging.

Atalie C Thompson, Tyler Mansfield, Eileen Johnson, Peggy M Cawthon, Elsa S Strotmeyer, Jeff D Williamson, Steve Cummings, Theresa Mau, Stephen B Kritchevsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Atalie C ThompsonDepartment of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-2817-6417
Tyler MansfieldSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Eileen JohnsonSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Peggy M CawthonSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.ORCID 0000-0003-4938-9478
Elsa S StrotmeyerDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-4093-6036
Jeff D WilliamsonDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Steve CummingsSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Theresa MauSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.ORCID 0000-0003-4278-6438
Stephen B KritchevskyDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0003-3336-6781

Funding

Study of Muscle, Mobility and Aging: SOMMA2R01AG059416 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STEVEN RON CUMMINGS, Peggy Mannen Cawthon · 2018 to 2026
$70.3M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI STEPHEN B. KRITCHEVSKY · 2002 to 2026
$36.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Deep learning to quantify glaucomatous damage on fundus photographs for teleophthalmologyK23EY030897 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI THOMPSON, ATALIE C · 2020 to 2024
$968k
Clinical and Translational Science InstitutesNational Center for Advancing Translational Science UL1 0TR001420NCATS NIH HHS UL1 TR001420NEI NIH HHS K23 EY030897NEI NIH HHS K23EY030897NIA Claude D. Pepper Older Americans Independence Centers P30AG024827NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG059416NIA NIH HHS R01AG059416Wake Forest University P30AG021332
6 · The paper itself

Abstract

backgroundSensory and cognitive function can impact physical performance, but the relationship of multiple sensory impairments (SIs) with mobility in older adults is not well understood. We hypothesized that severity and number of SIs would be associated with worse timed physical mobility performance, and that cognitive processing speed would mediate the association.

methodsParticipants (N = 832) were older adults (mean age 76.3 ± 5.0 years; 59.4% women; 84.2% non-Hispanic White) who completed tests of physical performance, cognitive function, and multiple sensory domains. Separate linear regression models examined the association of SI with 400-m walk, expanded Short Physical Performance Battery (eSPPB), 4-square step test (FSST), and stair climb test. Cognitive measures of executive function/processing speed (Digit Symbol Coding [DSC] and Trail Making Test [Trails] B) were tested as potential mediators of the relationship between SI and physical performance.

resultsEach 1-point decrement in SI scale was associated with slower 400-m walking speed (β = -0.01 m/s, p = .03), lower eSPPB score (β = -0.05 points, p < .001), and longer FSST time (β = 0.20 seconds, p = .01), but there was no association with stair climb time. Using a causal mediation approach with DSC and Trails B as potential mediators, 47.9% of the association of SI with 400-m walk, 43.8% of the association of SI with eSPPB, and 56.7% of the association of multiple SI with FSST were mediated.

conclusionsGreater SIs were associated with worse physical performance in older adults, and the association was partially mediated by measures of cognitive processing speed and executive function. Future studies should investigate the temporal relationship between SIs, cognitive function, and physical function.

Indexed as

AgingMobility LimitationPhysical Functional PerformanceSensation DisordersAgedAged, 80 and overCognitionExecutive FunctionFemaleGeriatric AssessmentHumansMaleWalking SpeedCognitionFunctional performanceGaitSensory

Identifiers

PMID40151944
PMCPMC12104803

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.