Evidence map›Paper›PMID 40151947›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Pyruvate kinase modulates the link between β-cell fructose metabolism and insulin secretion.

Naoya Murao, Risa Morikawa, Yusuke Seino, Kenju Shimomura, Yuko Maejima, Tamio Ohno, Norihide Yokoi, Yuichiro Yamada, Atsushi Suzuki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Pyruvate kinase modulates the link between β-cell fructose metabolism and insulin secretion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Naoya MuraoDepartment of Endocrinology, Diabetes and Metabolism, Fujita Health University, School of Medicine, Toyoake, Japan.ORCID https://orcid.org/0000-0002-7424-4476
Risa MorikawaDepartment of Endocrinology, Diabetes and Metabolism, Fujita Health University, School of Medicine, Toyoake, Japan.ORCID https://orcid.org/0009-0004-1918-2649
Yusuke SeinoDepartment of Endocrinology, Diabetes and Metabolism, Fujita Health University, School of Medicine, Toyoake, Japan.ORCID https://orcid.org/0000-0002-9099-3493
Kenju ShimomuraDepartment of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.ORCID https://orcid.org/0000-0002-1539-2532
Yuko MaejimaDepartment of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.ORCID https://orcid.org/0000-0001-5370-5758
Tamio OhnoGraduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering Division for Research of Laboratory Animals, Graduate School of Medicine, Nagoya University, Nagoya, Japan.ORCID https://orcid.org/0009-0005-9248-2880
Norihide YokoiLaboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0002-5596-9754
Yuichiro YamadaDepartment of Endocrinology, Diabetes and Metabolism, Fujita Health University, School of Medicine, Toyoake, Japan.ORCID https://orcid.org/0000-0003-1623-0815
Atsushi SuzukiDepartment of Endocrinology, Diabetes and Metabolism, Fujita Health University, School of Medicine, Toyoake, Japan.ORCID https://orcid.org/0000-0003-0807-199X

Funding

Daiwa Securities Health FoundationFujita Health UniversityHori Sciences and Arts FoundationJapan Association for Diabetes Education and Care (JADEC)Japan Diabetes FoundationManpei Suzuki Diabetes FoundationMEXT | Japan Society for the Promotion of Science (JSPS) JP22K20869MEXT | Japan Society for the Promotion of Science (JSPS) JP23K15401Suzuken Memorial Foundation
6 · The paper itself

Abstract

The intricate link between glucose metabolism, ATP production, and glucose-stimulated insulin secretion (GIIS) in pancreatic β-cells has been well established. However, the effects of other digestible monosaccharides on this mechanism remain unclear. This study examined the interaction between intracellular fructose metabolism and GIIS using MIN6-K8 β-cell lines and mouse pancreatic islets. Fructose at millimolar concentrations potentiated insulin secretion in the presence of stimulatory levels (8.8 mM) of glucose. This potentiation was dependent on sweet taste receptor-activated phospholipase Cβ2 (PLCβ2) signaling. Concurrently, metabolic tracing using

Indexed as

FructoseInsulinInsulin-Secreting CellsInsulin SecretionPyruvate KinaseAdenosine TriphosphateAnimalsCell LineGlucoseIslets of LangerhansMaleMiceMice, Inbred C57BLPhospholipase C betaSignal TransductionAdenosine TriphosphateFructoseGlucoseInsulinPhospholipase C betaPyruvate Kinasediabetes mellitusfructoseglycolysisinsulin secretionpancreatic beta cellspyruvate kinase

Identifiers

PMID40151947
PMCPMC11950909

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.