Evidence map›Paper›PMID 40152089›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Iridium-Catalyzed Asymmetric Allenylic Substitution via Kinetic Resolution Enabled by New Monodentate Ligands.

Youshao Tu, Xiangfeng Lin, Jie Lin, Chaoshen Zhang, Jianwei Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Rapid Access to an Enantioenriched Spiro Bisindole Directly from Indole and Acetone.Angewandte Chemie (International ed. in English) · 2025
    Article
  4. Photoinduced Copper-Catalyzed Enantioselective Allylic C(Journal of the American Chemical Society · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Youshao TuDepartment of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction The Hong Kong, University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, 99907, China.
Xiangfeng LinDepartment of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction The Hong Kong, University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, 99907, China.
Jie LinDepartment of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction The Hong Kong, University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, 99907, China.
Chaoshen ZhangDepartment of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction The Hong Kong, University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, 99907, China.
Jianwei SunDepartment of Chemistry and the Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration & Reconstruction The Hong Kong, University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, 99907, China.

Funding

Hong Kong Research Grants Council 16303420Hong Kong Research Grants Council 16304322Hong Kong Research Grants Council 16309321Hong Kong Research Grants Council 16309722Hong Kong Research Grants Council C6012-21 GInnovation and Technology CommissionNational Natural Science Foundation of China 22271242National Natural Science Foundation of China 22471232
6 · The paper itself

Abstract

Iridium-catalyzed asymmetric allenylic substitution represents a useful method for the construction of allenes bearing an allenylic central chirality, but current success has uniformly relied on only one specific chiral bidentate ligand. Herein, we address the limitation by the design of a new type of monodentate ligands leading to not only excellent enantiocontrol in allenylic substitution but also efficient kinetic resolution of α-allenylic alcohols, a new phenomenon never observed before in iridium-catalyzed allenylic substitution. This is also a rare demonstration of the non-enzymatic kinetic resolution of α-allenylic alcohols. A range of highly enantioenriched allenylic diarylmethanes and α-allenylic alcohols could be accessed under mild conditions. Control experiments and DFT studies indicated that this process proceeds by an S

Indexed as

AllenesAllenylic substitutionChiral ligandIridiumKinetic resolution

Identifiers

PMID40152089
PMCPMC12124433

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.