Evidence mapPaperPMID 40152935Full record

ArticleKidney3602025

Activin A Antagonism with Follistatin Reduces Kidney Fibrosis, Injury, and Cellular Senescence-Associated Inflammation in Murine Diabetic Kidney Disease.

Xiaohui Bian, Zachary K Snow, Caroline J Zinn, Cody C Gowan, Sabena M Conley, Anastasia L Bratulin, Khaled M Elhusseiny, Jordan Miller, Tamar Tchkonia, James L Kirkland and 2 more

Abstract read
In one paragraph

Article in Kidney360, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Integrative Approaches to Treating Cellular Senescence in Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaohui BianDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0009-0008-1952-0141
Zachary K SnowDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0009-0006-6407-3390
Caroline J ZinnDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-9099-172
Cody C GowanDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0009-0007-0829-0187
Sabena M ConleyDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.
Anastasia L BratulinDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0000-0001-9263-0891
Khaled M ElhusseinyDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-2230-2160
Jordan MillerDepartment of Surgery, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-9868-4097
Tamar TchkoniaDivision of Endocrinology and Metabolism, Department of Medicine, Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, California.
James L KirklandDivision of Endocrinology and Metabolism, Department of Medicine, Center for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Los Angeles, California.ORCID 0000-0003-1676-4905
Lilach O LermanDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-3271-3887
LaTonya J HicksonDivision of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.ORCID 0000-0002-7485-336

Funding

Effect of Aging on Preadipocyte DifferentiationR01AG013925 · BOSTON MEDICAL CENTER · 1997 to 2005
$2.1M
Obesity-induced mesenchymal stem cell senescenceR01DK120292 · NIDDK · MAYO CLINIC ROCHESTER · PI Lilach O Lerman · 2021 to 2022
$1.3M
KIDNEY DISEASES RESEARCH TRAINING PROGRAMT32DK007013 · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · 1986 to 2005
$839k
Effect of Aging on Preadipocyte DifferentiationR37AG013925 · CEDARS-SINAI MEDICAL CENTER · 2025 to 2025
$708k
Obesity-induced dysfunction of human MSC in peripheral microvascular repairR01HL158691 · MAYO CLINIC ROCHESTER · 2025 to 2025
$692k
Extracellular vesicle-based senotherapeutics for aging diabetic kidneydiseaseR01AG076537 · MAYO CLINIC JACKSONVILLE · 2025 to 2025
$567k
Mayo Clinic Nephrology & Urology Summer Undergraduate Research Fellowship (nuSURF)R25DK101405 · MAYO CLINIC ROCHESTER · 2025 to 2025
$132k
NHLBI NIH HHS R01 HL158691NIA NIH HHS AG076537NIA NIH HHS R01 AG013925NIA NIH HHS R01 AG076537NIA NIH HHS R37 AG013925NIDDK NIH HHS DK076169NIDDK NIH HHS DK115255NIDDK NIH HHS K08 DK118120NIDDK NIH HHS K23 DK109134NIDDK NIH HHS R01 DK120292NIDDK NIH HHS R03 DK123492NIDDK NIH HHS R25 DK101405NIDDK NIH HHS T32 DK007013NIDDK NIH HHS U24 DK076169NIDDK NIH HHS U24 DK115255NIH HHS AG076537NIH HHS DK07013NIH HHS DK101405NIH HHS DK109134NIH HHS DK118120NIH HHS DK120292NIH HHS DK123492NIH HHS HL158691NIH HHS NIH AG013925Regenerative Medicine Minnesota RMM 091718CT
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chronic inflammationdiabetic nephropathyfibronectinlymphocytesmacrophagespodocyterenal fibrosisrenal protectionrenal proximal tubule cell

Identifiers

PMID40152935
PMCPMC12407135

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.