Evidence map›Paper›PMID 40153028›Full record

ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2025

Inflammatory pain and electroacupuncture: how the P2X3 receptor can help modulate inflammation-a review of current literature.

Jardel Cristiano Ecco, Adinei Abadio Soares, Keroli Eloiza Tessaro da Silva, Vinicius Ansolin, Guilherme Vinício Sousa Silva, Débora Tavares Resende E Silva

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jardel Cristiano EccoDepartment of Graduate Studies in Biomedical Sciences, Federal University of Fronteira Sul (UFFS), Rodovia SC 484 - Km 02, Fronteira Sul, Chapecó, Santa Catarina, CEP 89815-899, Brazil.ORCID https://orcid.org/0000-0001-9751-1488
Adinei Abadio SoaresDepartment of Medicine, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.ORCID https://orcid.org/0009-0003-3572-4586
Keroli Eloiza Tessaro da SilvaDepartment of Graduate Studies in Biomedical Sciences, Federal University of Fronteira Sul (UFFS), Rodovia SC 484 - Km 02, Fronteira Sul, Chapecó, Santa Catarina, CEP 89815-899, Brazil.ORCID https://orcid.org/0000-0001-5737-057X
Vinicius AnsolinDepartment of Nursing, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.ORCID https://orcid.org/0009-0005-4837-4874
Guilherme Vinício Sousa SilvaDepartment of Medicine, Federal University of Fronteira Sul, Chapecó, Santa Catarina, Brazil.ORCID http://orcid.org/0000-0002-3170-6503
Débora Tavares Resende E SilvaDepartment of Graduate Studies in Biomedical Sciences, Federal University of Fronteira Sul (UFFS), Rodovia SC 484 - Km 02, Fronteira Sul, Chapecó, Santa Catarina, CEP 89815-899, Brazil. debora.silva@uffs.edu.br.ORCID http://orcid.org/0000-0002-3813-7139

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimInflammatory pain arises from tissue stress or injury and is initiated by signaling molecules that stimulate the immune and nervous systems. Evidence suggests that purinergic signaling pathways can modulate pain and inflammation through the activation of P1 and P2 purinergic receptors, such as the P2X3 receptor, which are stimulated by extracellular molecules like adenosine triphosphate (ATP). Electroacupuncture (EA) exhibits precise mechanisms that modulate inflammatory pain through the activation of the P2X3 receptor.

objectiveThis review analyzed evidence regarding the role of electroacupuncture and the purinergic system, particularly the P2X3 receptor, in modulating inflammation and pain. MATERIALS AND

methodsA search for the most relevant articles available in the SciVerse Scopus and MEDLINE/PubMed databases was conducted for publications from 1995 to 2024. Articles were initially selected by reading the title, abstract, and main text, respectively.

resultsIt was found that the P2X3 receptor, as well as the molecules activating purinergic receptors, such as ATP and adenosine, have the potential to regulate pain and inflammation. Additionally, EA can modulate the purinergic system in an anti-inflammatory response. EA may stimulate analgesia mainly through the conversion of ATP to adenosine, a crucial molecule in pain control.

conclusionThe purinergic system directly influences inflammatory pain and controls inflammation. In this context, EA has the potential to orchestrate this system to control pain and inflammation.

Indexed as

ElectroacupunctureInflammationPainPain ManagementReceptors, Purinergic P2X3Adenosine TriphosphateAnimalsHumansAdenosine TriphosphateReceptors, Purinergic P2X3ElectroacupunctureInflammatory painP2X3 receptorPurinergic signaling

Identifiers

PMID40153028

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.