Evidence map›Paper›PMID 40153161›Full record

ArticleBulletin of experimental biology and medicine2025

Expression of the Extracellular Domain of the Thyrotropin Receptor Based on mRNA Isolated from Thyroid Tissue and Whole Blood of Patients with Toxic Diffuse Goiter (Graves' Disease).

A V Zubkov, L G Butova, N S Kuzmina, I V Zubkova, V V Fadeev, O A Svitich

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A V ZubkovI. Mechnikov Research Institute of Vaccine and Sera, Moscow, Russia. alex_zubkov@list.ru.
L G ButovaI. Mechnikov Research Institute of Vaccine and Sera, Moscow, Russia.
N S KuzminaI. Mechnikov Research Institute of Vaccine and Sera, Moscow, Russia.
I V ZubkovaI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
V V FadeevI. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
O A SvitichI. Mechnikov Research Institute of Vaccine and Sera, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fragments of the thyrotropin receptor gene (TSHR) encoding 432- and 389-bp regions of the extracellular domain corresponding to the autoantibody binding sites in autoimmune diseases of the thyroid gland (Graves' disease and Hashimoto's thyroiditis, respectively) were cloned based on mRNA isolated not only from the thyroid tissue, but also from the whole blood of patients with toxic diffuse goiter (Graves' disease). In a group of 18 patients, the 432-bp fragment was detected in 6 patients and the 389-bp fragment was detected in 3 patients. In one patient, both fragments were isolated from the blood. The results indicate that TSHR is expressed in the blood in 30% of patients with Graves' disease.

Indexed as

Graves DiseaseReceptors, ThyrotropinRNA, MessengerThyroid GlandAdultAgedCloning, MolecularFemaleHashimoto DiseaseHumansMaleMiddle AgedProtein DomainsReceptors, ThyrotropinRNA, MessengerTSHR protein, humanextracellular domain of TSHRrecombinant vectorthyroid autoantigens

Identifiers

PMID40153161

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.