Evidence map›Paper›PMID 40155049›Full record

ArticleLife science alliance2025

A novel human organoid model system reveals requirement of TCF4 for oligodendroglial differentiation.

Federica Furlanetto, Nicole Flegel, Marco Kremp, Chiara Spear, Franziska Fröb, Margherita Alfonsetti, Bettina Bohl, Mandy Krumbiegel, Sören Turan, Andre Reis and 5 more

Abstract read
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Federica FurlanettoInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0003-0963-3560
Nicole FlegelInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Marco KrempInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0003-4174-2644
Chiara SpearInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0009-0004-9706-1463
Franziska FröbInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Margherita AlfonsettiInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-0261-3148
Bettina BohlInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0003-0373-7836
Mandy KrumbiegelInstitute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Sören TuranInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Andre ReisInstitute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-6301-6363
Dieter C LieInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-6035-6442
Jürgen WinklerDepartment of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Sven FalkInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany sven.falk@fau.de.ORCID 0000-0003-4194-9274
Michael WegnerInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany michael.wegner@fau.de.ORCID 0000-0002-4586-3294
Marisa KarowInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany marisa.karow@fau.de.ORCID 0000-0003-4935-1365

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heterozygous mutations of

Indexed as

Cell DifferentiationOligodendrogliaOrganoidsTranscription Factor 4FaciesHumansHyperventilationIntellectual DisabilityMutationNeural Stem CellsOligodendrocyte Transcription Factor 2SOXE Transcription FactorsTranscription FactorsOLIG2 protein, humanOligodendrocyte Transcription Factor 2SOX10 protein, humanSOXE Transcription FactorsTCF4 protein, humanTranscription Factor 4Transcription Factors

Identifiers

PMID40155049
PMCPMC11953572

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.