Trial reportOdontology2025
Effect of tricalcium silicate-based intracanal dressing on bone resorption and inflammatory mediators in periapical lesions: a randomized controlled clinical trial.
Trial report in Odontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06307678 (EFFECT OF CALCIUM SILICATE-BASED ROOT CANAL MEDICAMENT ON RELEASE OF BONE RESORPTION AND INFLAMMATION MEDIATORS IN PERIAPICAL LESIONS), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of calcium silicate-based root canal medicament on release of bone resorption and inflammation mediators in periapical lesions: a randomised controlled clinical trial
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Regenerative Potential of Biodentine in Complex Endodontic Conditions: A Systematic Review of Clinical and Radiological Evidence.Medicina (Kaunas, Lithuania) · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
This study aimed to investigate the effect of tricalcium silicate- and calcium hydroxide-based intracanal dressing on the release of nuclear factor kappa B ligand (RANKL), osteoprotegerin (OPG), tumor necrosis factor-alpha (TNF-α), prostaglandin-E2 (PGE-2), and transforming growth factor-beta (TGF-β) in asymptomatic periapical lesions. The 60 patients included in the study were randomly divided into two groups according to the intracanal dressing. After removing gutta-percha from the root canals, RANKL, OPG, TNF-α, PGE-2, and TGF-β samples were obtained from the apical tissues using three paper cones and the selected dressing material was placed into the canals. In the second appointment, the dressing was removed, and the second samples were taken using the same method. Pre-treatment and post-treatment RANKL, OPG, TNF-α, PGE-2, and TGF-β levels were determined using an enzyme-linked immunosorbent assay test. Data were analysed using t-test, the Mann-Whitney U test, the Wilcoxon test, The Fisher-Freeman-Halton test, and Path analysis. No significant difference was found between the groups in terms of demographic variables (age, gender, tooth region, and smoking) (p > 0.05). There was a statistically significant decrease in RANKL/OPG, TNF-α, PGE-2, and TGF-β levels before and after treatment in both groups (p < 0.05). A significant difference was observed in the percentage change of RANKL/OPG, TNF-α, and TGF-β ratios between the groups (p < 0.05). A statistically higher decrease in RANKL/OPG, TNF-α, and TGF-β levels was observed in the calcium hydroxide-based intracanal dressing group (p < 0.05). No significant difference was observed between the groups in terms of PGE-2 percentage change (p > 0.05). Tricalcium silicate-based intracanal dressing effectively reduced RANKL/OPG, TNF-α, PGE-2, and TGF-β levels in periapical lesions, but calcium hydroxide-based intracanal dressing resulted in a higher percentage reduction in RANKL/OPG, TNF-α, and TGF-β levels. The effects of both medicaments on PGE-2 levels were similar.Trial registration The study was registered in clinical trials database on 12 March 2024 ( https://www.clinicaltrials.gov ). Registration number: NCT06307678.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.