Evidence map›Paper›PMID 40155683›Full record

ArticleNPJ digital medicine2025

A clinically interpretable model derived from skin conductance for assessing microangiopathy of the skin surface.

Ximing Zhu, ShihChun Chu, Jie Fu, Siyu Ao, Tingting Liu, Ziming Liao, Jiamei Song, Yuhong Wang, Yanping Guo, Qinghong Song and 4 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ximing Zhu *Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, PR China.
ShihChun Chu *Department of Vascular Surgery, The Second Affiliated Hospital of Zhejiang University's Medical College, Hangzhou, 310051, China.
Jie FuAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, PR China.
Siyu AoAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, PR China.
Tingting LiuDepartment of Laboratory Diagnosis, The 971th Hospital, Qingdao, 266072, PR China.
Ziming LiaoAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, PR China.
Jiamei SongAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, PR China.
Yuhong WangGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 510100, PR China.
Yanping GuoSchool of Medicine, South China University of Technology, Guangdong, 510641, China.
Qinghong SongDepartment of Vascular Surgery, Tianjin People's Hospital (Nankai University Affiliated Hospital), Tianjin, 300121, China.
Pengfei LiuAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, PR China. feipengliu@tju.edu.cn.
Shuang LiAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, PR China. lishuangv@tju.edu.cn.
Bing ChenDepartment of Vascular Surgery, The Second Affiliated Hospital of Zhejiang University's Medical College, Hangzhou, 310051, China. cbobc99@163.com.
Bin YaoAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, PR China. hongyaobin_1212@tju.edu.cn.

Funding

Applied Basic Research Foundation of Tianjin 22JCQNJC00360National Key Research and Development Program of China 2022YFC2403100Natural Science Foundation of Tianjin 21JCQNJC01070Shandong Province Natural Science Foundation Youth Project ZR2021QC085Tianjin Health Research Project TJWJ2023QN050Tianjin Health Research Project ZC20112
6 · The paper itself

Abstract

The electrical properties of the skin can reflect changes in its structure and physiological state, and bioimpedance analysis has been widely used to distinguish specific components of the human body, such as water, fat, or muscle tissue, instead of the traditional examinations with bulky equipment gradually. For the assessment of microangiopathy, a low-cost, simple, effective, and clinically interpretable model was proposed that relies on individual skin conductance data, collected from 28 patients with lower extremity arterial occlusion. The model demonstrated a specificity of 67.4% and a sensitivity of 82.9% in classifying healthy-affected sides. The severity estimates were consistent with the patient's laser speckle and ankle-brachial index, with intra-class correlation coefficients of 0.43 and 0.55. Further, patient record data was combined to improve accuracy by about 15% in multimodal ensemble learning, indicating the potential for using the electrical properties of the skin to characterize surface microcirculation disorders.

Identifiers

PMID40155683
PMCPMC11953216

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.