Evidence map›Paper›PMID 40155685›Full record

ArticleScientific reports2025

Effects of the fatty acid synthase inhibitors triclosan and lapatinib on dengue virus and Zika virus infection.

Suthatta Sornprasert, Janejira Jaratsittisin, Chanida Chumchanchira, Duncan R Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The inhibition mechanism ofFrontiers in microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Suthatta SornprasertInstitute of Molecular Biosciences, Center for Advanced Therapeutics, Mahidol University, Nakhon Pathom, 73170, Thailand.ORCID http://orcid.org/0009-0009-7794-1638
Janejira JaratsittisinInstitute of Molecular Biosciences, Center for Advanced Therapeutics, Mahidol University, Nakhon Pathom, 73170, Thailand.ORCID http://orcid.org/0000-0002-0651-5377
Chanida ChumchanchiraInstitute of Molecular Biosciences, Center for Advanced Therapeutics, Mahidol University, Nakhon Pathom, 73170, Thailand.ORCID http://orcid.org/0009-0008-9193-5050
Duncan R SmithInstitute of Molecular Biosciences, Center for Advanced Therapeutics, Mahidol University, Nakhon Pathom, 73170, Thailand. duncan_r_smith@hotmail.com.ORCID http://orcid.org/0000-0002-6592-9852

Funding

Mahidol University fiscal year 2023 by National Science Research and Innovation FundNational Research Council of Thailand NRCT5- RGJ63012-139National Research Council of Thailand NRCT5-RSA63015-03
6 · The paper itself

Abstract

Fatty acid synthase (FASN) has been shown to be critical in the replication of several viruses of the genus Orthoflavivirus. In this study the role two inhibitors of FASN that work through different mechanisms were investigated in dengue virus (DENV) and Zika virus (ZIKV) infections. Triclosan is a FASN inhibitor that targets the enol reductase domain of FASN, while lapatinib exerts an effect on FASN through acting on HER2, an upstream regulator of FASN. After determining cytotoxicity, a comprehensive analysis of the effect of these drugs in DENV 2 and ZIKV infection was undertaken. The results showed that triclosan had moderate antiviral activity against both DENV 2 (EC

Indexed as

Antiviral AgentsDengueDengue VirusFatty Acid SynthasesLapatinibTriclosanZika VirusZika Virus InfectionAnimalsChlorocebus aethiopsHumansMolecular Docking SimulationVero CellsVirus ReplicationAntiviral AgentsFatty Acid SynthasesLapatinibTriclosan

Identifiers

PMID40155685
PMCPMC11953471

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.