Evidence map›Paper›PMID 40155977›Full record

ArticleMolecular cytogenetics2025

Genomic landscape of childhood acute lymphoblastic leukemia in Malaysia: insights from array-CGH.

Azli Ismail, Fadly Ahid, Wong Nyuk Moi, Nor Rizan Kamaluddin, Ezalia Esa, Yuslina Mat Yusoff, Zahidah Abu Seman, Muhammad Asyraff Mohammed, Elizabeth George, Asmida Isa and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cytogenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Azli Ismail *Hematology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, 40170, Malaysia.
Fadly Ahid *Centre for Medical Laboratory Technology Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam, Selangor, 42300, Malaysia. fadlyahid@uitm.edu.my.
Wong Nyuk MoiMedical Laboratory Technology College, Ministry of Health Malaysia, Kuala Lumpur, 50588, Malaysia.
Nor Rizan KamaluddinHematology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, 40170, Malaysia.
Ezalia EsaHematology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, 40170, Malaysia.
Yuslina Mat YusoffHematology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, 40170, Malaysia.
Zahidah Abu SemanHematology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, 40170, Malaysia.
Muhammad Asyraff MohammedHematology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, 40170, Malaysia.
Elizabeth GeorgeFaculty of Medical and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, 43400, Malaysia.
Asmida IsaDepartment of Biomedical Science, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Pulau Pinang, 13200, Malaysia.
Zubaidah ZakariaPremier Integrated Labs, Pantai Hospital Ampang, Kuala Lumpur, 55100, Malaysia.

Funding

Kementerian Kesihatan Malaysia NMRR-11-927-10333Ministry of Higher Education, Malaysia FRGS-EC/1/2024/STG01/UITM/02/20
6 · The paper itself

Abstract

backgroundAcute lymphoblastic leukemia (ALL) is the most common childhood cancer, comprising approximately 25% of pediatric malignancies. Notably, chromosomal aberrations and genetic alterations play a central role in the pathogenesis of ALL, serving as critical diagnostic and prognostic markers. In this study, we use array-based comparative genomic hybridization (array-CGH) to explore the landscape of copy number variations (CNVs) and variants of uncertain significance (VUS) in 67 Malaysian childhood ALL patients with normal karyotype.

resultsA total of 36 pathogenic CNVs (26 gains, 10 losses) were identified in 19 (28.4%) patients which harbor genes related to the development of ALL. The genes include the MLLT3 (9p21.3), ETV6 (12p13.2), RUNX1 (21q22.12), ERG (21q22.2) and DMD (Xp21.1). On the other hand, a total of 46 variants of uncertain significance (VUS) was observed in 34 (50.7%) patients.

conclusionsOur study indicates that array-CGH is able to identify and characterize the CNVs responsible for the pathogenesis of childhood ALL. However, further studies are required to determine the pathogenic implications of VUS in the development of childhood ALL.

Indexed as

Array-based comparative genomic hybridizationChildhood acute lymphoblastic leukemiaCopy number variationsVariants of uncertain significance

Identifiers

PMID40155977
PMCPMC11951632

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.