Evidence map›Paper›PMID 40155997›Full record

Trial reportStem cell research & therapy2025

Examining the effect of intermittent cycling throughout a 3-h period on peripheral blood concentrations of haemopoietic stem and progenitor cells and cytolytic natural killer cells.

Phoebe A Cox, Fendi Pradana, Ella Noble, Samuel J E Lucas, Guy Pratt, Mark T Drayson, Kevin Amin, Francesca A M Kinsella, Alex J Wadley

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Phoebe A CoxSchool of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Fendi PradanaSchool of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Ella NobleSchool of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Samuel J E LucasSchool of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Guy PrattBirmingham Centre for Cellular Therapy and Transplantation, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Mark T DraysonClinical Immunology Service, University of Birmingham, Birmingham, UK.
Kevin AminSchool of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Francesca A M KinsellaInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Alex J WadleySchool of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK. a.j.wadley@bham.ac.uk.ORCID http://orcid.org/0000-0002-1820-8446

Funding

Physiological Society 1001214
6 · The paper itself

Abstract

backgroundPeripheral blood stem cell (PBSC) donation is the primary procedure used to collect haemopoietic stem and progenitor cells (HSPCs) for haemopoietic stem cell transplants (HSCT), however there is a clinical need to reduce collection times and achieve sufficient HSPC doses for successful engraftment. Short bouts of interval cycling transiently enrich peripheral blood with HSPCs and cytolytic natural killer (CD56

methodsIn a randomised crossover design, 18 adults (9 young: 22.7 ± 3.2 years, 9 older: 65.2 ± 12.9 years) completed 3 × 3-h trials: high-intensity interval exercise (HIIE, 9 × 2-min cycling at 80-85% heart rate (HR)max/9 × 18 min rest), moderate-intensity interval exercise (MIIE, 9 × 4-min cycling at 65-70% HRmax/9 × 16 min rest) and REST (180 min). Immune cell subsets, including HSPCs and CD56

resultsBy design, MIIE elicited lower average and peak HR and rating of perceived exertion than HIIE and was reported as more enjoyable. All cell subset concentrations increased following each interval of MIIE and HIIE. Across all participants, the estimated cell dose of total lymphocytes, monocytes, T cells, CD56

conclusionPersistent mobilisation of peripheral blood immune cells throughout 3 h of MIIE and HIIE evoked sustained numbers of CD56

Indexed as

Hematopoietic Stem CellsKiller Cells, NaturalAdultAgedCD56 AntigenCross-Over StudiesExerciseFemaleHematopoietic Stem Cell MobilizationHematopoietic Stem Cell TransplantationHigh-Intensity Interval TrainingHumansMaleMiddle AgedYoung AdultCD56 AntigenExerciseFeasibilityHSPCInterval cyclingNatural killer cellPeripheral blood stem cell donationTransplantation

Identifiers

PMID40155997
PMCPMC11951530

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.