Evidence map›Paper›PMID 40156642›Full record

ArticleClinical and experimental medicine2025

YY1-induced transcription of AKR1C3 activates the Hedgehog signalling pathway to enhance lenalidomide resistance and glycolytic activity in multiple myeloma cells.

Yang Chen, Aijia Zhang, Yuan Wang, Daoda Qi, Chengyi Peng, Zihao Liang, Jingjing Guo, Yan Gu

Abstract read
In one paragraph

Article in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang Chen *Department of Geriatrics, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Aijia Zhang *Department of Geriatrics, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Yuan Wang *Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Daoda QiDepartment of Geriatrics, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Chengyi PengDepartment of Geriatrics, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Zihao LiangClinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Jingjing GuoDepartment of Geriatrics, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, People's Republic of China. guojingjing0017@126.com.
Yan GuDepartment of Geriatrics, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, People's Republic of China. guyan703@foxmail.com.

Funding

Geriatric Health Research Project of Jiangsu Provincial Health Commission LKM2022037Key Project of Research Project of Jiangsu Provincial Health Commission K2023018Nanjing Second Hospital Talent Promotion Project RCMS232013
6 · The paper itself

Abstract

Lenalidomide (LEN) is a mainstay for treating multiple myeloma (MM), but its efficacy is often limited by resistance. We investigated the interaction between aldo-keto reductase family 1 member C3 (AKR1C3) and Yin Yang 1 (YY1) and their roles in LEN resistance. We induced LEN-resistant MM cell lines (H929R and U266R). Loss- or gain-of-function assays of AKR1C3 and YY1 were used to analyse the half maximal inhibitory concentration (IC

Indexed as

Aldo-Keto Reductase Family 1 Member C3Drug Resistance, NeoplasmGlycolysisHedgehog ProteinsLenalidomideMultiple MyelomaYY1 Transcription FactorCell Line, TumorGene Expression Regulation, NeoplasticHumansSignal TransductionAKR1C3 protein, humanAldo-Keto Reductase Family 1 Member C3Hedgehog ProteinsLenalidomideYY1 protein, humanYY1 Transcription FactorAKR1C3GlycolysisHedgehog pathwayLenalidomide resistanceMultiple myelomaYY1

Identifiers

PMID40156642
PMCPMC11954848

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.