ArticleThe Journal of biological chemistry2025
The cardioprotective role of the G protein-coupled receptor FFAR4 in atherosclerosis is independent of macrophage foam cell regulation.
Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- AldehydeFrontiers in medicine · 2026Article
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5 authors.
Funding
Abstract
Free fatty acid receptor 4 (FFAR4), also known as G protein-coupled receptor 120, is a long-chain unsaturated fatty acid receptor expressed in multiple tissue types including macrophages. Activation of FFAR4 maintains metabolic homeostasis by regulating adipogenesis, insulin sensitivity, and inflammation. While FFAR4 is best known for its protective role in obesity and diabetes, recent studies have demonstrated that FFAR4 may also prevent the development of atherosclerosis and cardiovascular disease. Given FFAR4's importance in anti-inflammatory signaling in macrophages, we used peritoneal macrophages from WT and FFAR4 KO (Ffar4
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Registered trials
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